In enzymology, a biotin—CoA ligase (EC 6.2.1.11) is an enzyme that catalyzes the chemical reaction

Biotin—CoA ligase
Identifiers
EC no.6.2.1.11
CAS no.37318-60-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
ATP + biotin + CoA AMP + diphosphate + biotinyl-CoA

The 3 substrates of this enzyme are ATP, biotin, and CoA, whereas its 3 products are AMP, diphosphate, and biotinyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is biotin:CoA ligase (AMP-forming). Other names in common use include biotinyl-CoA synthetase, biotin CoA synthetase, and biotinyl coenzyme A synthetase. This enzyme participates in biotin metabolism.

References

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  • CHRISTNER JE, SCHLESINGER MJ, COON MJ (1964). "ENZYMATIC ACTIVATION OF BIOTIN. BIOTINYL ADENYLATE FORMATION". J. Biol. Chem. 239: 3997–4005. PMID 14257635.