In enzymology, a biphenyl synthase (EC 2.3.1.177) is an enzyme that catalyzes the chemical reaction:

Biphenyl synthase
Identifiers
EC no.2.3.1.177
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins
3 malonyl-CoA + benzoyl-CoA 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2

Thus, the two substrates of this enzyme are malonyl-CoA and benzoyl-CoA, whereas its three products are CoA, 3,5-dihydroxybiphenyl, and CO2.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:benzoyl-CoA malonyltransferase. This enzyme is also called BIS.

References

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  • Liu B, Beuerle T, Klundt T, Beerhues L (2004). "Biphenyl synthase from yeast-extract-treated cell cultures of Sorbus aucuparia". Planta. 218 (3): 492–6. doi:10.1007/s00425-003-1144-y. PMID 14595561.