Blanche is the surname of:
- August Blanche (1811–1868), Swedish journalist, novelist and socialist politician
- Bartolomé Blanche (1879–1970), Chilean brigadier general, briefly provisional president of Chile in 1932
- Francis Blanche (1921–1974), French actor and humorist
- Fred A. Blanche Jr. (1921–1997), Justice of the Louisiana Supreme Court
- Jacques-Émile Blanche (1861–1942), French artist
- John Blanche (fl. 1950s–2010s), illustrator
- Margot Blanche (born 1983), pop singer
- Roland Blanche (1943–1999), French actor
- Tember Blanche, Ukrainian musical duo