Bone morphogenetic protein 8A

Bone morphogenetic protein 8A (BMP8A) is a protein that in humans is encoded by the BMP8A gene.

BMP8A
Identifiers
Aliases	BMP8A, entrez:353500, bone morphogenetic protein 8a, OP-2
External IDs	MGI: 104515; HomoloGene: 135983; GeneCards: BMP8A; OMA:BMP8A - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.3 Start 39,491,636 bp End 39,529,869 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 D2.2|4 57.42 cM Start 123,206,438 bp End 123,237,045 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland periodontal fiber tibia C1 segment left ovary right ovary islet of Langerhans smooth muscle tissue tibial nerve Top expressed in decidua gastrula intestinal villus calvaria hair follicle molar jejunum embryo Ileal epithelium body of femur More reference expression data BioGPS n/a
Gene ontology Molecular function transforming growth factor beta receptor binding cytokine activity BMP receptor binding growth factor activity Cellular component extracellular region extracellular space Biological process regulation of apoptotic process multicellular organism development positive regulation of pathway-restricted SMAD protein phosphorylation cartilage development negative regulation of insulin secretion cell differentiation regulation of MAPK cascade SMAD protein signal transduction cell development BMP signaling pathway ossification diet induced thermogenesis regulation of signaling receptor activity energy homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 353500 12163 Ensembl ENSG00000183682 ENSMUSG00000032726 UniProt Q7Z5Y6 P34821 RefSeq (mRNA) NM_181809 NM_001256019 NM_007558 RefSeq (protein) NP_861525 NP_001242948 NP_031584 Location (UCSC) Chr 1: 39.49 – 39.53 Mb Chr 4: 123.21 – 123.24 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

BMP8A is a polypeptide member of the TGFβ superfamily of proteins. It, like other bone morphogenetic proteins (BMPs), is involved in the development of bone and cartilage. BMP8A may be involved in epithelial osteogenesis. It also plays a role in bone homeostasis. It is a disulfide-linked homodimer.

External links

• Human BMP8A genome location and BMP8A gene details page in the UCSC Genome Browser.

Further reading

• Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496. S2CID 11183658.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.