Bonfiglio is a surname. Notable people with the surname include:
- Charles J. Bonfiglio (born 1962), American businessman
- Óscar Bonfiglio (1905-1987), Mexican football player
- Pascual Bonfiglio (1907-?), Argentine boxer
- Robert Bonfiglio (born 1950), American harmonica player
- Stefano Bonfiglio (born 1964), Italian businessman
- Jeremy D. Bonfiglio (born 1970), American journalist
- Susanna Bonfiglio (born 1974), Italian basketball player