Borrero is a family name of Spanish origin. Originally from Leon, Spain, It may refer to:
- Antonio Borrero (1827-1911), Ecuadorian politician, President of Ecuador 1875-1876
- Ariel Borrero (born 1972), Cuban baseball player
- Francisco Manuel de las Heras y Borrero (1951–2013), Spanish historian
- Gloria María Borrero (born 1956), Colombian justice minister
- Ismael Borrero (born 1992), Cuban sport wrestler
- José Ignacio Borrero (1921-2004), Colombian ornithologist
- Juana Borrero (1877-1896), Cuban painter and poet
- Julia Emilia Valdés Borrero (1952), Cuban artist
- Lía Borrero, Panamanian beauty queen
- Manuel María Borrero (1883–1975), President of Ecuador in 1938
- Misael Pastrana Borrero (1923-1997), Colombian politician, President of Colombia 1970-1974
- Ramón Borrero y Cortázar (1824–1895), brother of Antonio Borrero, President of Ecuador 1883-1884
- Yordanis Borrero (born 1978), Cuban weightlifter