Botelho is a surname, or part of a combined surname. Notable people with the surname include:
- Abel Botelho (1855/6–1917), Portuguese military officer, diplomat and writer
- Bruce Botelho (born 1948), American attorney and politician in Alaska
- Carlos Botelho (1899–1982), Portuguese painter and cartoonist
- Carlos Botelho, Brazilian minister
- João Botelho (born 1949), Portuguese film director
- Júlio Botelho (1929–2003), also known as Julinho, Brazilian footballer
- Martiniano Ferreira Botelho, Portuguese doctor, politician and philanthropist
- Mauricio Botelho, former chairman of Embraer
- Poliana Botelho (born 1988), Brazilian mixed martial artist
- Rogério Márcio Botelho (born 1979), Brazilian footballer
People with the combined surname:
- José Maria Botelho de Vasconcelos, Angolan politician and government minister
- Júlio Botelho Moniz (1900–1970), Portuguese military officer and politician
- Pedro Roberto Silva Botelho (born 1989), Portuguese footballer