Brevican core protein is a protein that in humans is encoded by the BCAN gene.[5][6][7] Brevican is a member of the lectican protein family.

BCAN
Identifiers
AliasesBCAN, BEHAB, CSPG7, Brevican
External IDsOMIM: 600347; MGI: 1096385; HomoloGene: 7244; GeneCards: BCAN; OMA:BCAN - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021948
NM_198427

NM_001109758
NM_007529

RefSeq (protein)

NP_068767
NP_940819

NP_001103228
NP_031555

Location (UCSC)Chr 1: 156.64 – 156.66 MbChr 3: 87.99 – 88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Brevican is localised to the surface of neurons in the brain.[8] In melanocytic cells, BCAN gene expression may be regulated by MITF.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132692Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004892Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gary SC, Zerillo CA, Chiang VL, Gaw JU, Gray G, Hockfield S (Oct 2000). "cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma". Gene. 256 (1–2): 139–47. doi:10.1016/S0378-1119(00)00362-0. PMID 11054543.
  6. ^ Nomoto H, Oohashi T, Hirakawa S, Ueki Y, Ohtsuki H, Ninomiya Y (Feb 2002). "Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23". Acta Medica Okayama. 56 (1): 25–9. PMID 11873941.
  7. ^ "Entrez Gene: BCAN brevican".
  8. ^ Frischknecht R, Seidenbecher CI (Jul 2012). "Brevican: a key proteoglycan in the perisynaptic extracellular matrix of the brain". The International Journal of Biochemistry & Cell Biology. 44 (7): 1051–4. doi:10.1016/j.biocel.2012.03.022. PMID 22537913.
  9. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Further reading

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