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Brian Kuhlman

Brian A. Kuhlman is an American professor of biochemistry and biophysics at the UNC School of Medicine of University of North Carolina at Chapel Hill and a Sloan Research Fellow.

Early life

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Kuhlman obtained Bachelor of Arts degree in chemical physics from Rice University in 1992. From 1993 to 1998 he studied under guidance of Daniel Raleigh to earn his Ph.D. in chemistry from Stony Brook University and from 1999 to 2002 he studied under guidance from David Baker to obtain Damon Runyon Postdoctoral Fellowship at the University of Washington.

Career

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In 2003, Kuhlman designed the first full-domain artificial protein, Top7, with Gautam Dantas and other researchers, in David Baker's laboratory. In his independent research laboratory, Kuhlman continued pioneering research in protein design, including breakthroughs in design of protein conformational switches,[1] protein interface design, design of protein loops,[2] stitching together components of natural proteins,[3] designed fusions for bispecific antibodies,[4] and progress toward vaccines.[5]

Awards

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References

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  1. ^ Ambroggio, X.; et al. (2006). "Computational design of a single amino acid sequence that can switch between two distinct protein folds". J Am Chem Soc. 128 (4): 1154–61. doi:10.1021/ja054718w. PMID 16433531.
  2. ^ Hu, X.; et al. (2007). "High-resolution design of a protein loop". Proc Natl Acad Sci U S A. 104 (45): 17668–73. Bibcode:2007PNAS..10417668H. doi:10.1073/pnas.0707977104. PMC 2077077. PMID 17971437.
  3. ^ "Frankenstein Proteins Stitched Together by Scientists". May 11, 2016. Retrieved August 13, 2019.
  4. ^ Lewis, Steven M.; et al. (2014). "Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface". Nature Biotechnology. 32 (2): 191–8. doi:10.1038/nbt.2797. PMID 24463572. S2CID 10961481.
  5. ^ "Researchers discover how body temperature wrecks potential dengue, Zika vaccine". ScienceDaily. May 18, 2018. Retrieved August 13, 2019.
  6. ^ "Kuhlman wins DeLano Award for computer applications to enhance research". UNC Health Care. July 5, 2018. Retrieved August 13, 2019.
  7. ^ "Brian Kuhlman, Ph.D., Protein Robotics: Making Science Fun while Improving Human Health". UNC Health Care. September 1, 2018. Retrieved August 13, 2019.
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