Bridging integrator 2

Bridging integrator 2 is a protein that in humans is encoded by the BIN2 gene.

BIN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4AVM, 4I1Q
Identifiers
Aliases	BIN2, BRAP-1, bridging integrator 2
External IDs	OMIM: 605936; MGI: 3611448; HomoloGene: 22965; GeneCards: BIN2; OMA:BIN2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.13 Start 51,281,038 bp End 51,324,668 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 F1 Start 100,538,958 bp End 100,567,434 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood bone marrow cells spleen trabecular bone lymph node appendix right lung upper lobe of left lung Top expressed in granulocyte secondary oocyte spleen thymus primary oocyte placenta zygote bone marrow yolk sac testicle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding phospholipid binding Cellular component cytoplasm podosome cell junction plasma membrane cell projection cell cortex phagocytic cup membrane extracellular region secretory granule lumen ficolin-1-rich granule lumen Biological process cell chemotaxis podosome assembly phagocytosis, engulfment plasma membrane tubulation neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51411 668218 Ensembl ENSG00000110934 ENSMUSG00000098112 UniProt Q9UBW5 D3Z6Q9 RefSeq (mRNA) NM_001290007 NM_001290008 NM_001290009 NM_016293 NM_001364779 NM_001364780 NM_001364781 NM_001270537 NM_001368666 RefSeq (protein) NP_001276936 NP_001276937 NP_001276938 NP_057377 NP_001351708 NP_001351709 NP_001351710 n/a Location (UCSC) Chr 12: 51.28 – 51.32 Mb Chr 15: 100.54 – 100.57 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Ge K, Prendergast GC (July 2000). "Bin2, a functionally nonredundant member of the BAR adaptor gene family". Genomics. 67 (2): 210–20. doi:10.1006/geno.2000.6216. PMID 10903846.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Bridging integrator 2