Bruce Smith (born 1963) is a retired American football player who holds the NFL record for most career quarterback sacks.
Bruce Smith may also refer to:
- Bruce Smith (halfback) (1920–1967), American football player, nicknamed "Boo," winner of the 1941 Heisman Trophy
- Bruce Smith (Australian footballer) (born 1944), Australian rules footballer for Richmond
- Bruce Smith (Australian politician) (1851–1937), member of the Australian House of Representatives
- Bruce Smith (Canadian football) (1949–2013), Canadian football player
- Bruce Smith (cricketer) (born 1946), New Zealand cricketer
- Bruce Smith (luger) (born 1958), Canadian luger
- Bruce Smith (Ontario politician), former member of the Legislative Assembly of Ontario
- Bruce Smith (musician), former drummer with The Pop Group
- Bruce Smith (poet) (born 1946), American poet
- Bruce Smith (New Zealand politician), New Zealand mayor
- Bruce Smith (rugby union) (born 1959), New Zealand rugby union player
- Bruce Atherton Smith (1937–2006), member of the Legislative Assembly of New Brunswick
- Bruce D. Smith (born 1946), archaeologist and curator at Smithsonian Institution
- Bruce I. Smith (born 1934), Member of the Pennsylvania House of Representatives
- Bruce Lannes Smith (1909–1987), American political scientist and communication theorist
- Bruce W. Smith (born 1961), African-American animator, film director, and television producer