In molecular biology, the Btz domain (CASC3/Barentsz eIF4AIII binding domain) is a protein domain found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.[1][2]
| Btz | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of the human exon junction complex with a trapped dead-box helicase bound to RNA | |||||||||
| Identifiers | |||||||||
| Symbol | Btz | ||||||||
| Pfam | PF09405 | ||||||||
| InterPro | IPR018545 | ||||||||
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References
edit- ^ Bono F, Ebert J, Lorentzen E, Conti E (August 2006). "The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA". Cell. 126 (4): 713–25. doi:10.1016/j.cell.2006.08.006. PMID 16923391. S2CID 16137076.
- ^ Palacios IM, Gatfield D, St Johnston D, Izaurralde E (February 2004). "An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay". Nature. 427 (6976): 753–7. doi:10.1038/nature02351. PMID 14973490. S2CID 4400243.