C-C motif chemokine ligand 24

C-C motif chemokine ligand 24 is a protein that in humans is encoded by the CCL24 gene.

CCL24
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EIG, 1EIH
Identifiers
Aliases	CCL24, Ckb-6, MPIF-2, MPIF2, SCYA24, C-C motif chemokine ligand 24
External IDs	OMIM: 602495; MGI: 1928953; HomoloGene: 2248; GeneCards: CCL24; OMA:CCL24 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q11.23 Start 75,810,825 bp End 75,823,356 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 G2 Start 135,598,791 bp End 135,601,903 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum spleen mucosa of transverse colon appendix duodenum lymph node jejunal mucosa right coronary artery mucosa of sigmoid colon upper lobe of left lung Top expressed in muscle of thigh lip white adipose tissue esophagus skeletal muscle tissue jejunum migratory enteric neural crest cell subcutaneous adipose tissue dermis stomach More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity chemokine activity CCR3 chemokine receptor binding receptor ligand activity protein binding CCR chemokine receptor binding Cellular component extracellular region extracellular space Biological process eosinophil chemotaxis monocyte chemotaxis neutrophil chemotaxis positive regulation of endothelial cell proliferation positive regulation of ERK1 and ERK2 cascade positive regulation of GTPase activity positive regulation of angiogenesis G protein-coupled receptor signaling pathway cell-cell signaling positive regulation of eosinophil migration chemotaxis cytoskeleton organization lymphocyte chemotaxis positive regulation of cell migration cellular response to tumor necrosis factor chemokine-mediated signaling pathway cellular response to interleukin-1 cellular response to interferon-gamma positive regulation of actin filament polymerization signal transduction regulation of cell shape immune response inflammatory response positive regulation of inflammatory response regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6369 56221 Ensembl ENSG00000106178 ENSMUSG00000004814 UniProt O00175 Q9JKC0 RefSeq (mRNA) NM_002991 NM_001371193 NM_019577 NM_001356630 RefSeq (protein) NP_002982 NP_001358122 NP_062523 NP_001343559 Location (UCSC) Chr 7: 75.81 – 75.82 Mb Chr 5: 135.6 – 135.6 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. [provided by RefSeq, Jul 2008].

Further reading

• Papadopoulos NG, Papi A, Meyer J, Stanciu LA, Salvi S, Holgate ST, Johnston SL (July 2001). "Rhinovirus infection up-regulates eotaxin and eotaxin-2 expression in bronchial epithelial cells". Clin. Exp. Allergy. 31 (7): 1060–6. doi:10.1046/j.1365-2222.2001.01112.x. PMID 11467997. S2CID 20581201.
• Tachimoto H, Kikuchi M, Hudson SA, Bickel CA, Hamilton RG, Bochner BS (June 2002). "Eotaxin-2 alters eosinophil integrin function via mitogen-activated protein kinases". Am. J. Respir. Cell Mol. Biol. 26 (6): 645–9. doi:10.1165/ajrcmb.26.6.4741. PMID 12034562.
• Badewa AP, Hudson CE, Heiman AS (September 2002). "Regulatory effects of eotaxin, eotaxin-2, and eotaxin-3 on eosinophil degranulation and superoxide anion generation". Exp. Biol. Med. (Maywood). 227 (8): 645–51. doi:10.1177/153537020222700814. PMID 12192108. S2CID 32212646.
• Menzies-Gow A, Ying S, Sabroe I, Stubbs VL, Soler D, Williams TJ, Kay AB (September 2002). "Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers". J. Immunol. 169 (5): 2712–8. doi:10.4049/jimmunol.169.5.2712. PMID 12193745.
• Chae SC, Lee YC, Park YR, Shin JS, Song JH, Oh GJ, Hong ST, Pae HO, Choi BM, Chung HT (July 2004). "Analysis of the polymorphisms in eotaxin gene family and their association with asthma, IgE, and eosinophil". Biochem. Biophys. Res. Commun. 320 (1): 131–7. doi:10.1016/j.bbrc.2004.05.136. PMID 15207712.
• Chae SC, Park YR, Oh GJ, Lee JH, Chung HT (January 2005). "The suggestive association of eotaxin-2 and eotaxin-3 gene polymorphisms in Korean population with allergic rhinitis". Immunogenetics. 56 (10): 760–4. doi:10.1007/s00251-004-0746-2. PMID 15580493. S2CID 45416407.
• Min JW, Lee JH, Park CS, Chang HS, Rhim TY, Park SW, Jang AS, Shin HD (2005). "Association of eotaxin-2 gene polymorphisms with plasma eotaxin-2 concentration". J. Hum. Genet. 50 (3): 118–23. doi:10.1007/s10038-005-0230-3. PMID 15744457.
• Min JW, Jang AS, Park SM, Lee SH, Lee JH, Park SW, Park CS (November 2005). "Comparison of plasma eotaxin family level in aspirin-induced and aspirin-tolerant asthma patients". Chest. 128 (5): 3127–32. doi:10.1378/chest.128.5.3127. PMID 16304252.
• Park YR, Choi SC, Lee ST, Kim KS, Chae SC, Chung HT (December 2005). "The association of eotaxin-2 and eotaxin-3 gene polymorphisms in a Korean population with ulcerative colitis". Exp. Mol. Med. 37 (6): 553–8. doi:10.1038/emm.2005.68. PMID 16391516.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.