C-C motif chemokine ligand 3 like 3

CCL3L3
Identifiers
Aliases	CCL3L3, 464.2, D17S1718, G0S19-2, LD78, LD78BETA, SCYA3L, SCYA3L1, C-C motif chemokine ligand 3 like 3
External IDs	OMIM: 609468; MGI: 98260; HomoloGene: 2242; GeneCards: CCL3L3; OMA:CCL3L3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	36,196,758 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	83,540,181 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; monocyte; ; bone marrow cells; ; testicle; ; gonad; ; lymph node; ; appendix; ; blood; ; granulocyte; ; spleen;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; calvaria; ; spermatid; ; blood; ; dermis; ; secondary oocyte; ; thymus; ; islet of Langerhans; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	chemokine activity; cytokine activity; CCR chemokine receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	lymphocyte chemotaxis; chemokine-mediated signaling pathway; G protein-coupled receptor signaling pathway; positive regulation of GTPase activity; cellular response to tumor necrosis factor; chemotaxis; inflammatory response; cellular response to interleukin-1; monocyte chemotaxis; neutrophil chemotaxis; negative regulation of cell population proliferation; positive regulation of ERK1 and ERK2 cascade; immune response; cellular response to interferon-gamma; regulation of signaling receptor activity; cytokine-mediated signaling pathway; positive regulation of inflammatory response;
	Sources:Amigo / QuickGO
Orthologs
	414062
	20302
	ENSG00000276085
	ENSMUSG00000000982
	P16619
	P10855
	NM_001001437
	NM_011337
	NP_001001437; NP_066286
	NP_035467
	Wikidata
View/Edit Human	View/Edit Mouse

C-C motif chemokine ligand 3 like 3 is a protein that in humans is encoded by the CCL3L3 gene. ^[5]

Function

This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000276085 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000982 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: C-C motif chemokine ligand 3 like 3". Retrieved 2017-09-16.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This gene article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000276085 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000982 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: C-C motif chemokine ligand 3 like 3". Retrieved 2017-09-16.

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