C-myc internal ribosome entry site (IRES)

The c-myc internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of C-myc and allows cap-independent translation. The mammalian c-myc gene is a proto-oncogene which is required for cell proliferation, transformation and death. c-myc mRNA has an alternative method of translation via internal ribosome entry where ribosomes are recruited to the IRES located in the 5' UTR thus bypassing the typical eukaryotic cap-dependent translation pathway.[1]

c-myc internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_c-myc
Identifiers
SymbolIRES_c-myc
Alt. Symbolsc-myc_IRES
RfamRF00216
Other data
RNA typeCis-reg; IRES
Domain(s)Eukaryota
GOGO:0043022
SOSO:0000243
PDB structuresPDBe

References

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  1. ^ Le Quesne JP, Stoneley M, Fraser GA, Willis AE (June 2001). "Derivation of a structural model for the c-myc IRES". Journal of Molecular Biology. 310 (1): 111–126. doi:10.1006/jmbi.2001.4745. PMID 11419940.
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