The c-sis internal ribosome entry site (IRES) is a RNA element found in the 5' UTR of the PDGF beta chain gene. The internal ribosome entry site contains three modules that can individually mediate internal ribosome entry. However, the full length sequence is required for maximal IRES activity. It is thought that the three IRES elements are somehow responsive to cellular changes and act to regulate the level of translation.[1]
| c-sis internal ribosome entry site (IRES) | |
|---|---|
 Predicted secondary structure and sequence conservation of IRES_c-sis | |
| Identifiers | |
| Symbol | IRES_c-sis |
| Rfam | RF00549 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Eukaryota |
| GO | GO:0043022 |
| SO | SO:0000243 |
| PDB structures | PDBe |
References
edit- ^ Sella O, Gerlitz G, Le SY, Elroy-Stein O (August 1999). "Differentiation-induced internal translation of c-sis mRNA: analysis of the cis elements and their differentiation-linked binding to the hnRNP C protein". Molecular and Cellular Biology. 19 (8): 5429–5440. doi:10.1128/mcb.19.8.5429. PMC 84385. PMID 10409733.
External links
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