C5a peptidase (EC 3.4.21.110, streptococcal C5a peptidase, ScpA, ScpB, SCPA) is an enzyme.[1][2][3][4][5][6] The primary cleavage site is at His67-Lys68 in human C5a with a minor secondary cleavage site at Ala58-Ser59.
| C5a peptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.21.110 | ||||||||
| CAS no. | 100179-39-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is a surface-associated subtilisin-like serine peptidase with very specific substrate preference.
References
edit- ^ Wexler DE, Chenoweth DE, Cleary PP (December 1985). "Mechanism of action of the group A streptococcal C5a inactivator". Proceedings of the National Academy of Sciences of the United States of America. 82 (23): 8144–8. doi:10.1073/pnas.82.23.8144. PMC 391459. PMID 3906656.
- ^ Bohnsack JF, Mollison KW, Buko AM, Ashworth JC, Hill HR (February 1991). "Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus". The Biochemical Journal. 273 ( Pt 3) (3): 635–40. doi:10.1042/bj2730635. PMC 1149811. PMID 1996961.
- ^ Cleary PP, Prahbu U, Dale JB, Wexler DE, Handley J (December 1992). "Streptococcal C5a peptidase is a highly specific endopeptidase". Infection and Immunity. 60 (12): 5219–23. doi:10.1128/iai.60.12.5219-5223.1992. PMC 258300. PMID 1452354.
- ^ Anderson ET, Wetherell MG, Winter LA, Olmsted SB, Cleary PP, Matsuka YV (October 2002). "Processing, stability, and kinetic parameters of C5a peptidase from Streptococcus pyogenes". European Journal of Biochemistry. 269 (19): 4839–51. doi:10.1046/j.1432-1033.2002.03183.x. PMID 12354115.
- ^ Stafslien DK, Cleary PP (June 2000). "Characterization of the streptococcal C5a peptidase using a C5a-green fluorescent protein fusion protein substrate". Journal of Bacteriology. 182 (11): 3254–8. doi:10.1128/jb.182.11.3254-3258.2000. PMC 94514. PMID 10809707.
- ^ Terao Y, Yamaguchi M, Hamada S, Kawabata S (May 2006). "Multifunctional glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophils". The Journal of Biological Chemistry. 281 (20): 14215–23. doi:10.1074/jbc.M513408200. PMID 16565520.
External links
edit- C5a+peptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
