CDK5 and ABL1 enzyme substrate 1 is a protein that in humans is encoded by the CABLES1 gene.[5][6]

CABLES1
Identifiers
AliasesCABLES1, CABL1, CABLES, HsT2563, IK3-1, Cdk5 and Abl enzyme substrate 1
External IDsOMIM: 609194; MGI: 1927065; HomoloGene: 11097; GeneCards: CABLES1; OMA:CABLES1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001100619
NM_001256438
NM_138375

NM_001146287
NM_022021

RefSeq (protein)

NP_001094089
NP_001243367
NP_612384

NP_001139759
NP_071304

Location (UCSC)Chr 18: 23.13 – 23.26 MbChr 18: 11.97 – 12.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CABLES1 is a cyclin-dependent kinase (CDK)-binding protein that plays a role in proliferation and/or cell differentiation (Zukerberg et al., 2004).[supplied by OMIM].[6] It is a tumor suppressor gene which losing it (by mutations, knockout, knockdown or inactivation) may lead to colorectal cancer CRC.[citation needed]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134508Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040957Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  6. ^ a b "Entrez Gene: CABLES1 Cdk5 and Abl enzyme substrate 1".
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Further reading

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