CAMK1G (gene)

Calcium/calmodulin dependent protein kinase IG is a protein that in humans is encoded by the CAMK1G gene.

CAMK1G
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JAM
Identifiers
Aliases	CAMK1G, CLICK3, CLICKIII, VWS1, dJ272L16.1, calcium/calmodulin dependent protein kinase IG
External IDs	OMIM: 614994; MGI: 2388073; HomoloGene: 48706; GeneCards: CAMK1G; OMA:CAMK1G - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q32.2 Start 209,583,714 bp End 209,613,939 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 H6|1 97.74 cM Start 193,028,654 bp End 193,052,606 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in frontal pole Brodmann area 10 right frontal lobe Brodmann area 9 cingulate gyrus anterior cingulate cortex nucleus accumbens middle frontal gyrus Region I of hippocampus proper superior frontal gyrus Top expressed in ventromedial nucleus superior frontal gyrus visual cortex primary visual cortex olfactory tubercle pontine nuclei primary motor cortex central gray substance of midbrain nucleus accumbens nucleus of stria terminalis More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein serine/threonine kinase activity catalytic activity ATP binding kinase activity calmodulin-dependent protein kinase activity calmodulin binding Cellular component cytoplasm calcium- and calmodulin-dependent protein kinase complex neuron projection Golgi membrane plasma membrane Golgi apparatus membrane endomembrane system intracellular anatomical structure Biological process protein phosphorylation metabolism phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57172 215303 Ensembl ENSG00000008118 ENSMUSG00000016179 UniProt Q96NX5 Q91VB2 RefSeq (mRNA) NM_020439 NM_144817 RefSeq (protein) NP_065172 NP_659066 Location (UCSC) Chr 1: 209.58 – 209.61 Mb Chr 1: 193.03 – 193.05 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protein similar to calcium/calmodulin dependent protein kinase, however, its exact function is not known. [provided by RefSeq, Jul 2008].

Further reading

• Takemoto-Kimura S, Terai H, Takamoto M, Ohmae S, Kikumura S, Segi E, Arakawa Y, Furuyashiki T, Narumiya S, Bito H (May 2003). "Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK)". J. Biol. Chem. 278 (20): 18597–605. doi:10.1074/jbc.M300578200. PMID 12637513.
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
• Pang ZP, Xu W, Cao P, Südhof TC (October 2010). "Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons". J. Biol. Chem. 285 (44): 33930–9. doi:10.1074/jbc.M110.150151. PMC 2962493. PMID 20729199.
• Deng M, Wei L, Zuo X, Tian Y, Xie F, Hu P, Zhu C, Yu F, Meng Y, Wang H, Zhang F, Ma H, Ye R, Cheng H, Du J, Dong W, Zhou S, Wang C, Wang Y, Wang J, Chen X, Sun Z, Zhou N, Jiang Y, Liu X, Li X, Zhang N, Liu N, Guan Y, Han Y, Han Y, Lv X, Fu Y, Yu H, Xi C, Xie D, Zhao Q, Xie P, Wang X, Zhang Z, Shen L, Cui Y, Yin X, Cheng H, Liang B, Zheng X, Lee TM, Chen G, Zhou F, Veldink JH, Robberecht W, Landers JE, Andersen PM, Al-Chalabi A, Shaw C, Liu C, Tang B, Xiao S, Robertson J, Zhang F, van den Berg LH, Sun L, Liu J, Yang S, Ju X, Wang K, Zhang X (June 2013). "Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis". Nat. Genet. 45 (6): 697–700. doi:10.1038/ng.2627. PMID 23624525. S2CID 7924012.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.