Calmodulin-regulated spectrin-associated protein 1 (CAMSAP1) is a human protein encoded by the gene CAMSAP1. Like other CAMSAP-family proteins, it is a microtubule minus-end anchor, and binds microtubules through its CKK domain.[4]

CAMSAP1
Identifiers
AliasesCAMSAP1, PRO2405, bA100C15.1, calmodulin regulated spectrin associated protein 1
External IDsOMIM: 613774; MGI: 3036242; HomoloGene: 19202; GeneCards: CAMSAP1; OMA:CAMSAP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015447

NM_001115076
NM_001276359
NM_001276360
NM_001276361
NM_001372499

RefSeq (protein)

NP_056262

Location (UCSC)n/aChr 2: 25.82 – 25.87 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Clinical significance

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CAMSAP1 is vital for neuron polarisation, and so mice that lack CAMSAP1 die of epileptic seizures.[5]

See also

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References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026933Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Baines, A. J.; Bignone, P. A.; King, M. D.A.; Maggs, A. M.; Bennett, P. M.; Pinder, J. C.; Phillips, G. W. (2009-09-01). "The CKK Domain (DUF1781) Binds Microtubules and Defines the CAMSAP/ssp4 Family of Animal Proteins". Molecular Biology and Evolution. 26 (9): 2005–2014. doi:10.1093/molbev/msp115. ISSN 0737-4038. PMID 19508979.
  5. ^ Zhou Z, Xu H, Li Y, Yang M, Zhang R, Shiraishi A, et al. (September 2020). "CAMSAP1 breaks the homeostatic microtubule network to instruct neuronal polarity". Proceedings of the National Academy of Sciences of the United States of America. 117 (36): 22193–22203. Bibcode:2020PNAS..11722193Z. doi:10.1073/pnas.1913177117. PMC 7486724. PMID 32839317.