CANT1

CANT1 is a gene that encodes soluble calcium-activated nucleotidase 1, an enzyme, in humans.

CANT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1S18, 1S1D, 2H2N, 2H2U
Identifiers
Aliases	CANT1, DBQD, SCAN-1, SCAN1, SHAPY, DBQD1, calcium activated nucleotidase 1, EDM7
External IDs	OMIM: 613165; MGI: 1923275; HomoloGene: 69460; GeneCards: CANT1; OMA:CANT1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.3 Start 78,991,716 bp End 79,009,867 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 E2|11 83.15 cM Start 118,297,115 bp End 118,309,912 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell mucosa of transverse colon rectum mucosa of sigmoid colon mucosa of ileum stromal cell of endometrium blood tibia placenta germinal epithelium Top expressed in pyloric antrum gastrula duodenum intestinal villus spermatocyte large intestine colon epithelium of small intestine crypt of lieberkuhn of small intestine ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function uridine-diphosphatase activity hydrolase activity signal transducer activity nucleoside-diphosphatase activity metal ion binding calcium ion binding protein homodimerization activity adenosine-diphosphatase activity guanosine-diphosphatase activity pyrophosphatase activity Cellular component integral component of membrane Golgi cisterna membrane Golgi apparatus extracellular exosome endoplasmic reticulum membrane endoplasmic reticulum extracellular region plasma membrane membrane specific granule lumen tertiary granule lumen ficolin-1-rich granule lumen Biological process positive regulation of I-kappaB kinase/NF-kappaB signaling proteoglycan biosynthetic process signal transduction neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 124583 76025 Ensembl ENSG00000171302 ENSMUSG00000025575 UniProt Q8WVQ1 Q8VCF1 RefSeq (mRNA) NM_001159772 NM_001159773 NM_138793 NM_001025617 NM_001025618 NM_001267591 NM_001267592 NM_029502 RefSeq (protein) NP_001153244 NP_001153245 NP_620148 NP_001020788 NP_001020789 NP_001254520 NP_001254521 NP_083778 Location (UCSC) Chr 17: 78.99 – 79.01 Mb Chr 11: 118.3 – 118.31 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

External links

• Human CANT1 genome location and CANT1 gene details page in the UCSC Genome Browser.

Further reading

• Smith TM, Hicks-Berger CA, Kim S, Kirley TL (2002). "Cloning, expression, and characterization of a soluble calcium-activated nucleotidase, a human enzyme belonging to a new family of extracellular nucleotidases". Arch. Biochem. Biophys. 406 (1): 105–15. doi:10.1016/S0003-9861(02)00420-4. PMID 12234496.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Murphy DM, Ivanenkov VV, Kirley TL (2003). "Bacterial expression and characterization of a novel, soluble, calcium-binding, and calcium-activated human nucleotidase". Biochemistry. 42 (8): 2412–21. doi:10.1021/bi026763b. PMID 12600208.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Dai J, Liu J, Deng Y, et al. (2004). "Structure and protein design of a human platelet function inhibitor". Cell. 116 (5): 649–59. doi:10.1016/S0092-8674(04)00172-2. PMID 15006348. S2CID 15305441.
• Yang M, Kirley TL (2004). "Site-directed mutagenesis of human soluble calcium-activated nucleotidase 1 (hSCAN-1): identification of residues essential for enzyme activity and the Ca(2+)-induced conformational change". Biochemistry. 43 (28): 9185–94. doi:10.1021/bi049565o. PMID 15248776.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.