CAPRIN2

caprin family member 2, also known as CAPRIN2, is a human gene.

CAPRIN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4OUL, 4OUM
Identifiers
Aliases	CAPRIN2, C1QDC1, EEG-1, EEG1, RNG140, caprin family member 2
External IDs	OMIM: 610375; MGI: 2448541; HomoloGene: 11393; GeneCards: CAPRIN2; OMA:CAPRIN2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12p11.21 Start 30,709,552 bp End 30,754,951 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 G3 Start 148,743,990 bp End 148,797,735 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spinal ganglia cerebellar vermis right hemisphere of cerebellum trigeminal ganglion testicle sural nerve lateral nuclear group of thalamus pars compacta pars reticulata external globus pallidus Top expressed in lens epithelium of lens zygote primary oocyte secondary oocyte tail of embryo neural layer of retina lumbar spinal ganglion supraoptic nucleus paraventricular nucleus of hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function signaling receptor binding protein binding RNA binding metal ion binding Cellular component centrosome receptor complex nucleus mitochondrion cytoplasm cytosol plasma membrane membrane Biological process positive regulation of canonical Wnt signaling pathway regulation of growth cell differentiation negative regulation of translation positive regulation of protein binding negative regulation of cell growth positive regulation of peptidyl-serine phosphorylation positive regulation of transcription by RNA polymerase II positive regulation of dendrite morphogenesis positive regulation of dendritic spine morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 65981 232560 Ensembl ENSG00000110888 ENSMUSG00000030309 UniProt Q6IMN6 Q05A80 RefSeq (mRNA) NM_001002259 NM_001206856 NM_023925 NM_032156 NM_001319842 NM_001319843 NM_001319844 NM_001319845 NM_001319846 NM_001301351 NM_181541 RefSeq (protein) NP_001002259 NP_001193785 NP_001306771 NP_001306772 NP_001306773 NP_001306774 NP_001306775 NP_076414 NP_115532 NP_001288280 NP_853519 Location (UCSC) Chr 12: 30.71 – 30.75 Mb Chr 6: 148.74 – 148.8 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene may be involved in the transitioning of erythroblasts from a highly proliferative state to a terminal phase of differentiation. High level expression of the encoded protein can lead to apoptosis. Several transcript variants encoding different isoforms have been found for this gene.

External links

• Human CAPRIN2 genome location and CAPRIN2 gene details page in the UCSC Genome Browser.

Further reading

• Aerbajinai W, Lee YT, Wojda U, et al. (2004). "Cloning and characterization of a gene expressed during terminal differentiation that encodes a novel inhibitor of growth". J. Biol. Chem. 279 (3): 1916–21. doi:10.1074/jbc.M305634200. PMID 14593112.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Shiina N, Tokunaga M (2010). "RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain". J. Biol. Chem. 285 (31): 24260–9. doi:10.1074/jbc.M110.108944. PMC 2911287. PMID 20516077.
• Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.
• Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ding Y, Xi Y, Chen T, et al. (2008). "Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation". J. Cell Biol. 182 (5): 865–72. doi:10.1083/jcb.200803147. PMC 2528581. PMID 18762581.
• Grill B, Wilson GM, Zhang KX, et al. (2004). "Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins". J. Immunol. 172 (4): 2389–400. doi:10.4049/jimmunol.172.4.2389. PMID 14764709.