CBX7 (gene)

Chromobox homolog 7 is a protein that in humans is encoded by the CBX7 gene. The loss of CBX7 gene expression has been shown to correlate with a malignant form of thyroid cancer.

CBX7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K1B, 2L12, 2L1B, 3GS2, 4MN3, 5EPJ
Identifiers
Aliases	CBX7, chromobox 7
External IDs	OMIM: 608457; MGI: 1196439; HomoloGene: 65296; GeneCards: CBX7; OMA:CBX7 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.1 Start 39,120,167 bp End 39,152,680 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 E1|15 37.85 cM Start 79,800,008 bp End 79,855,320 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis paraflocculus of cerebellum Brodmann area 10 right hemisphere of cerebellum frontal pole gastric mucosa middle frontal gyrus pons right coronary artery right frontal lobe Top expressed in yolk sac spermatocyte neural layer of retina cerebellar cortex muscle of thigh superior frontal gyrus mesenteric lymph nodes epiblast lip right kidney More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding methylated histone binding chromatin binding single-stranded RNA binding Cellular component PcG protein complex nucleus nucleoplasm cytosol PRC1 complex Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated chromatin organization sebaceous gland development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23492 52609 Ensembl ENSG00000100307 ENSMUSG00000053411 UniProt O95931 Q8VDS3 RefSeq (mRNA) NM_175709 NM_001346743 NM_001346744 NM_144811 RefSeq (protein) NP_001333672 NP_001333673 NP_783640 NP_783640.1 NP_659060 Location (UCSC) Chr 22: 39.12 – 39.15 Mb Chr 15: 79.8 – 79.86 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Yap KL, Li S, Muñoz-Cabello AM, Raguz S, Zeng L, Mujtaba S, et al. (June 2010). "Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a". Molecular Cell. 38 (5): 662–74. doi:10.1016/j.molcel.2010.03.021. PMC 2886305. PMID 20541999.
• Federico A, Pallante P, Bianco M, Ferraro A, Esposito F, Monti M, et al. (September 2009). "Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein". Cancer Research. 69 (17): 7079–87. doi:10.1158/0008-5472.CAN-09-1542. PMID 19706751.
• Pallante P, Terracciano L, Carafa V, Schneider S, Zlobec I, Lugli A, et al. (August 2010). "The loss of the CBX7 gene expression represents an adverse prognostic marker for survival of colon carcinoma patients". European Journal of Cancer. 46 (12): 2304–13. doi:10.1016/j.ejca.2010.05.011. PMID 20542683.
• Zhang XW, Zhang L, Qin W, Yao XH, Zheng LZ, Liu X, et al. (August 2010). "Oncogenic role of the chromobox protein CBX7 in gastric cancer". Journal of Experimental & Clinical Cancer Research. 29 (1): 114. doi:10.1186/1756-9966-29-114. PMC 2933612. PMID 20723236.
• Hu CK, Wang W, Brind'Amour J, Singh PP, Reeves GA, Lorincz MC, Alvarado AS, Brunet A (February 2020). "Vertebrate diapause preserves organisms long term through Polycomb complex members". Science. 367 (6480): 870–874. Bibcode:2020Sci...367..870H. doi:10.1126/science.aaw2601. PMC 7532943. PMID 32079766.