Wikipedia

CCDC184

Coiled-coil domain-containing 184 (CCDC184) is a protein which, in humans, is encoded by the CCDC184 gene

CCDC184
Identifiers
AliasesCCDC184, C12orf68, coiled-coil domain containing 184
External IDsMGI: 2146066; HomoloGene: 18612; GeneCards: CCDC184; OMA:CCDC184 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

387856

239650

Ensembl

ENSG00000177875

ENSMUSG00000029875

UniProt

Q52MB2

Q8BMK5

RefSeq (mRNA)

NM_001013635

NM_177716

RefSeq (protein)

NP_001013657

NP_808384

Location (UCSC)Chr 12: 48.18 – 48.19 MbChr 15: 98.07 – 98.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gene

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Alias for the CCDC184 gene is C12orf68, chromosome 12 open reading frame 68.[5] CCDC184 mRNA sequence, which is 2283 nucleotides in length, and is composed of 1 exon.

 

Expression

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Human CCDC184 is primarily expressed in the components of the brain, such as hypothalamus, pons, pituitary gland.[6] The gene's expression is enhanced and/or over-expressed in the brain tissue expression.[7] Tissue expression cluster predicted Pituitary gland - Hormone signaling[8]

Protein

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Overview

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CCDC184 Protein is 194 amino acid and contains a domain of unknown function, DUF4677, which spans for 193 amino acid long . CCDC184 protein has a theoretical molecular weight of 20,484[9] dalton and an isoelectric point of 4.04.[10] This indicates the acidic nature of the sequence. The molecular function of the protein is protein binding[11]

Post translational Modification

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CCDC184 contains various predicted post-translational modification domains, including phosphorylation, SUMOylation, Glutaredoxin, Myristoylation, Glutamic acid-rich region, and acetylation. The phosphosphorylation sites include S23, T24, and Y36.[12]

Predicted Post Modification sites/domains of CCDC184 human protein.
Modification Amino acid Region
Phosphorylation 76, 113, 155, 120, 122, 162
Myristoylation 103-108, 109-114, 124-129, 166-172
Glutaredoxin domain 1-62
Glutamic acid-rich region 136-146
SUMOylation 102-106, 183-187
 
CCDC184 protein Domain, motif and post translational modification diagram

P = Phosphorylation site, Sumo: Sumo interacting regions, DUF4677: domain of unknown function

Structure

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The human CCDC184 protein is predicted to be localized in the cytoplasm[13]

 
AlphaFold figure indicates 3D model of CCDC184. The colors indicate the charged regions of the structure.

AlphaFold figure indicates 3D model of CCDC184. The colors indicate the charged regions of the structure

Conceptual translation

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The annotated elements shown in the conceptual translation for human CCDC184 protein is post-translational modifications, alpha helices, SUMOylation, Lysine acetylation, domain of unknown function.

Homology

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CCDC184 is found only in mammals. 183 organisms that have orthologs with the human gene CCDC184.

Table of Orthologs

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Orthologs for CCDC184 are only found in mammals. The most distantly related species to human CCDC184 with a date of divergence of 160 MYA is the opossum. The Tasmanian devil also has a date of divergence of 160 MYA. The table indicates a various selection portion of the mammals' list.

Table of Orthologs
Taxonomic Order Genus and Species Common Name Accession Number Sequence Length(aa) Date of Divergence(MYA) % Identity to the human protein % Similarity to the human protein
Primate Homo sapiens Human NP_001013657.3 194 0 100 100
Primate Carlito syrichta Philippine tarsier XP_008067440.1 194 69 93.3 97.4
Scandentina Tupaia chinensis Chinese tree shrew XP_006163517.1 85 85 89.7 93.8
Rodentia Mus musculus Mouse NP_808384.2 191 87 90.2 82.8
Carnivora Lontra canadensis River otter XP_032732811.1 193 94 93.8 96.9
Carnivora Ursus americanus American black bear XP_045656783.1 195 94 94.9 96.9
Cetacea Neophocaena asiaeorientalis asiaeorientalis Finless porpoise XP_024592814.1 195 94 92.8 95.9
Cetacea Delphinapterus leucas Beluga whale XP_022428046.1 195 94 93.3 96.4
Artiodactyla Camelus ferus Bactrian camel XP_006196007.2 195 94 94.9 97.4
Artiodactyla Sus scrofa Wild boar XP_020948280.1 195 94 92.8 95.4
Chiroptera Desmodus rotundus Vampire bat XP_024431436.1 195 94 90.3 93.8
Pilosa Choloepus didactylus Two-toed sloth XP_037701005.1 196 99 88.8 92.9
Proboscidea Elephas maximus indicus Indian elephant XP_049738921.1 197 99 89.3 94.9
Cingulata Dasypus novemcinctus Nine-banded armadillo XP_004470453.1 192 99 90.2 93.3
Marsupial Gracilinanus agilis Agile gracile opossum XP_044534020.1 186 160 72.8 80
Marsupial Sarcophilus harrisii Tasmanian devil XP_031793886.1 187 160 69.2 77.6

  The figure indicates a chart showing the divergence of CCDC184, Cytochrome C and Fibrogen Alpha.

Interaction and clinical significance

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Predicted interactions for the CCDC184 gene were seen and the interactions revolved around enabling protein binding activity. Expressions of CCDC184 were connected to studies done on tissue samples for breast cancer somatic mutations[14]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177875 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029875 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "NCBI Gene". NCBI Gene.
  6. ^ "Protein Atlas". Human Protein Atlas.
  7. ^ "Gene Card results for CCDC184". Gene Card.
  8. ^ "Human Protein Atlas". Human Protein Atlas.
  9. ^ "PhosphositePlus". PhosphositePlus.
  10. ^ "Expasy pI tool". ExPasy.
  11. ^ "PhosphositePlus". PhosphositePlus.
  12. ^ "PhosphositePlus". PhosphositePlus.
  13. ^ "PSORT II".
  14. ^ Mertins P, Mani DR, Ruggles KV, Gillette MA, Clauser KR, Wang P, et al. (June 2016). "Proteogenomics connects somatic mutations to signalling in breast cancer". Nature. 534 (7605). NLM: 55–62. Bibcode:2016Natur.534...55.. doi:10.1038/nature18003. PMC 5102256. PMID 27251275.
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