CCNL2

Cyclin-L2 is a protein that in humans is encoded by the CCNL2 gene. The protein encoded by this gene belongs to cyclin family.

CCNL2
Identifiers
Aliases	CCNL2, ANIA-6B, CCNM, CCNS, HCLA-ISO, HLA-ISO, PCEE, SB138, cyclin L2
External IDs	OMIM: 613482; MGI: 1927119; HomoloGene: 69477; GeneCards: CCNL2; OMA:CCNL2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.33 Start 1,385,711 bp End 1,399,335 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 E2|4 87.47 cM Start 155,896,946 bp End 155,909,000 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right hemisphere of cerebellum right ovary left ovary body of uterus canal of the cervix left lobe of thyroid gland right lobe of thyroid gland gastric mucosa left uterine tube Top expressed in granulocyte medullary collecting duct body of femur Ileal epithelium fossa lymph node condyle conjunctival fornix lobe of cerebellum trachea More reference expression data BioGPS n/a
Gene ontology Molecular function cyclin-dependent protein serine/threonine kinase regulator activity protein binding Cellular component nucleus cyclin-dependent protein kinase holoenzyme complex intracellular membrane-bounded organelle nuclear speck nucleoplasm Biological process regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of phosphorylation of RNA polymerase II C-terminal domain positive regulation of cyclin-dependent protein serine/threonine kinase activity transcription, DNA-templated regulation of cyclin-dependent protein serine/threonine kinase activity regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81669 56036 Ensembl ENSG00000221978 ENSMUSG00000029068 UniProt Q96S94 Q9JJA7 RefSeq (mRNA) NM_001039577 NM_001144867 NM_001144868 NM_030937 NM_001320153 NM_001320155 NM_001350497 NM_001350498 NM_001350499 NM_001350500 NM_018856 NM_207678 NM_001401306 RefSeq (protein) NP_001034666 NP_001307082 NP_001307084 NP_112199 NP_001337426 NP_001337427 NP_001337428 NP_001337429 NP_997561 NP_001388235 Location (UCSC) Chr 1: 1.39 – 1.4 Mb Chr 4: 155.9 – 155.91 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

CCNL2 gene also called

Cyclin L2	HLA-ISO
Paneth Cell-Enhanced Expression Protein	SB138
Cyclin S	CCNS
Cyclin M	PCEE
Cyclin-L2	CCNM
HCLA-ISO
ANIA-6B

Table Source: genecards.org

External links

• Human CCNL2 genome location and CCNL2 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Cheng H, Bjerknes M (1996). "Patterns of gene expression along the crypt-villus axis in mouse jejunal epithelium". Anat. Rec. 244 (1): 78–94. doi:10.1002/(SICI)1097-0185(199601)244:1<78::AID-AR8>3.0.CO;2-B. PMID 8838426. S2CID 11890083.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• de Graaf K, Hekerman P, Spelten O, et al. (2004). "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors". J. Biol. Chem. 279 (6): 4612–24. doi:10.1074/jbc.M310794200. PMID 14623875.
• Yang L, Li N, Wang C, et al. (2004). "Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells". J. Biol. Chem. 279 (12): 11639–48. doi:10.1074/jbc.M312895200. PMID 14684736.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.