CCT8

T-complex protein 1 subunit theta is a protein that in humans is encoded by the CCT8 gene. The CCT8 protein is a component of the TRiC complex.

CCT8
Identifiers
Aliases	CCT8, C21orf112, Cctq, D21S246, PRED71, chaperonin containing TCP1 subunit 8
External IDs	OMIM: 617786; MGI: 107183; HomoloGene: 4802; GeneCards: CCT8; OMA:CCT8 - orthologs
Gene location (Human) Chr. Chromosome 21 (human) Band 21q21.3 Start 29,055,805 bp End 29,073,797 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 C3.3 Start 87,280,214 bp End 87,292,761 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte gonad secondary oocyte epithelium of nasopharynx embryo ganglionic eminence endothelial cell germinal epithelium Epithelium of choroid plexus ventricular zone Top expressed in otic placode otic vesicle epiblast mandibular prominence maxillary prominence saccule somite primitive streak abdominal wall tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding ATP binding protein folding chaperone activity unfolded protein binding cadherin binding Cellular component cell body cytosol centrosome cell projection cilium nucleoplasm microtubule organizing center zona pellucida receptor complex intermediate filament cytoskeleton microtubule extracellular exosome cytoskeleton cytoplasm chaperonin-containing T-complex extracellular region secretory granule lumen azurophil granule lumen ficolin-1-rich granule lumen Biological process positive regulation of protein localization to Cajal body positive regulation of establishment of protein localization to telomere pore complex assembly protein stabilization positive regulation of telomere maintenance via telomerase toxin transport positive regulation of telomerase RNA localization to Cajal body binding of sperm to zona pellucida protein folding 'de novo' protein folding neutrophil degranulation chaperone-mediated protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10694 12469 Ensembl ENSG00000156261 ENSMUSG00000025613 UniProt P50990 P42932 RefSeq (mRNA) NM_006585 NM_001282907 NM_001282908 NM_001282909 NM_009840 RefSeq (protein) NP_001269836 NP_001269837 NP_001269838 NP_006576 NP_033970 Location (UCSC) Chr 21: 29.06 – 29.07 Mb Chr 16: 87.28 – 87.29 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• TCP1, T-complex protein 1 subunit alpha
• Chaperonin

External links

• Human CCT8 genome location and CCT8 gene details page in the UCSC Genome Browser.

Further reading

• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Yamazaki M, Ono A, Watanabe K, et al. (1996). "Nucleotide sequence surrounding the locus marker D21S246 on human chromosome 21". DNA Res. 2 (4): 187–9. doi:10.1093/dnares/2.4.187. PMID 8590283.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
• Hynes GM, Willison KR (2000). "Individual subunits of the eukaryotic cytosolic chaperonin mediate interactions with binding sites located on subdomains of beta-actin". J. Biol. Chem. 275 (25): 18985–94. doi:10.1074/jbc.M910297199. PMID 10748209.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
• Yokota S, Yanagi H, Yura T, Kubota H (2001). "Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle". Eur. J. Biochem. 268 (17): 4664–73. doi:10.1046/j.1432-1327.2001.02393.x. PMID 11532003.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Imai Y, Soda M, Murakami T, et al. (2004). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". J. Biol. Chem. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Wang L, Zhu YF, Guo XJ, et al. (2006). "A two-dimensional electrophoresis reference map of human ovary". J. Mol. Med. 83 (10): 812–21. doi:10.1007/s00109-005-0676-y. PMID 16021519. S2CID 6644433.
• Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
• Kim SC, Sprung R, Chen Y, et al. (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey". Mol. Cell. 23 (4): 607–18. doi:10.1016/j.molcel.2006.06.026. PMID 16916647.