CD109

CD109 (Cluster of Differentiation 109) is a human gene.

CD109
Identifiers
Aliases	CD109, CPAMD7, p180, r150, CD109 molecule
External IDs	OMIM: 608859; MGI: 2445221; HomoloGene: 25183; GeneCards: CD109; OMA:CD109 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q13 Start 73,695,785 bp End 73,828,316 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 E1 Start 78,522,828 bp End 78,623,535 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia skin of arm skin of thigh skin of hip synovial membrane vulva tendon of biceps brachii cartilage tissue nipple gums Top expressed in skin of external ear calvaria spermatid body of femur skin of back ankle cornea endothelial cell of lymphatic vessel lip stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity endopeptidase inhibitor activity transforming growth factor beta binding serine-type endopeptidase inhibitor activity Cellular component cell surface anchored component of membrane membrane extracellular region extracellular space plasma membrane platelet alpha granule membrane Biological process hair follicle development negative regulation of protein phosphorylation regulation of keratinocyte differentiation osteoclast fusion negative regulation of wound healing negative regulation of peptidase activity negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of keratinocyte proliferation negative regulation of endopeptidase activity platelet degranulation C-terminal protein lipidation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 135228 235505 Ensembl ENSG00000156535 ENSMUSG00000046186 UniProt Q6YHK3 Q8R422 RefSeq (mRNA) NM_001159587 NM_001159588 NM_133493 NM_153098 RefSeq (protein) NP_001153059 NP_001153060 NP_598000 NP_694738 Location (UCSC) Chr 6: 73.7 – 73.83 Mb Chr 9: 78.52 – 78.62 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

CD109 is a GPI-linked cell surface antigen expressed by CD34+ acute myeloid leukemia cell lines, T-cell lines, activated T lymphoblasts, endothelial cells, and activated platelets (Lin et al., 2002). In addition, the platelet-specific Gov antigen system (HPA15), implicated in refractoriness to platelet transfusion, neonatal alloimmune thrombocytopenia, and posttransfusion purpura, is carried by CD109 (Kelton et al., 1990; Lin et al., 2002).[supplied by OMIM]

See also

• Cluster of differentiation

Further reading

• Lucas GF, Metcalfe P (2000). "Platelet and granulocyte glycoprotein polymorphisms". Transfusion Medicine (Oxford, England). 10 (3): 157–74. doi:10.1046/j.1365-3148.2000.00250.x. PMID 10972910. S2CID 43709043.
• Sutherland DR, Yeo E, Ryan A, et al. (1991). "Identification of a cell-surface antigen associated with activated T lymphoblasts and activated platelets". Blood. 77 (1): 84–93. doi:10.1182/blood.V77.1.84.84. PMID 1984805.
• Kelton JG, Smith JW, Horsewood P, et al. (1990). "Gova/b alloantigen system on human platelets". Blood. 75 (11): 2172–6. doi:10.1182/blood.V75.11.2172.2172. PMID 2346781.
• Lin M, Sutherland DR, Horsfall W, et al. (2002). "Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins". Blood. 99 (5): 1683–91. doi:10.1182/blood.V99.5.1683. PMID 11861284.
• Schuh AC, Watkins NA, Nguyen Q, et al. (2002). "A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens". Blood. 99 (5): 1692–8. doi:10.1182/blood.V99.5.1692. PMID 11861285.
• Giesert C, Marxer A, Sutherland DR, et al. (2003). "Antibody W7C5 defines a CD109 epitope expressed on CD34+ and CD34- hematopoietic and mesenchymal stem cell subsets". Ann. N. Y. Acad. Sci. 996 (1): 227–30. Bibcode:2003NYASA.996..227G. doi:10.1111/j.1749-6632.2003.tb03250.x. PMID 12799300. S2CID 24117857.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Solomon KR, Sharma P, Chan M, et al. (2004). "CD109 represents a novel branch of the alpha2-macroglobulin/complement gene family". Gene. 327 (2): 171–83. doi:10.1016/j.gene.2003.11.025. PMID 14980714.
• Zhang JM, Hashimoto M, Kawai K, et al. (2005). "CD109 expression in squamous cell carcinoma of the uterine cervix". Pathol. Int. 55 (4): 165–9. doi:10.1111/j.1440-1827.2005.01807.x. PMID 15826242. S2CID 24693926.
• Lewandrowski U, Moebius J, Walter U, Sickmann A (2006). "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach". Mol. Cell. Proteomics. 5 (2): 226–33. doi:10.1074/mcp.M500324-MCP200. PMID 16263699.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Finnson KW, Tam BY, Liu K, et al. (2006). "Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes". FASEB J. 20 (9): 1525–7. doi:10.1096/fj.05-5229fje. PMID 16754747. S2CID 30768709.
• Sjöblom T, Jones S, Wood LD, et al. (2006). "The consensus coding sequences of human breast and colorectal cancers". Science. 314 (5797): 268–74. Bibcode:2006Sci...314..268S. doi:10.1126/science.1133427. PMID 16959974. S2CID 10805017.
• Hasegawa M, Hagiwara S, Sato T, et al. (2007). "CD109, a new marker for myoepithelial cells of mammary, salivary, and lacrimal glands and prostate basal cells". Pathol. Int. 57 (5): 245–50. doi:10.1111/j.1440-1827.2007.02097.x. PMID 17493171. S2CID 23930267.

External links

• CD109+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CD109 genome location and CD109 gene details page in the UCSC Genome Browser.