CD177

CD177 antigen is a protein that in humans is encoded by the CD177 gene.

CD177
Identifiers
Aliases	CD177, HNA-2a, HNA2A, NB1, NB1 GP, PRV-1, PRV1, CD177 molecule
External IDs	OMIM: 162860; MGI: 1916141; HomoloGene: 49628; GeneCards: CD177; OMA:CD177 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.31 Start 43,353,686 bp End 43,363,172 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 A3 Start 24,443,408 bp End 24,459,736 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum mucosa of colon mucosa of sigmoid colon mucosa of transverse colon bone marrow bone marrow cells spleen trabecular bone prostate blood Top expressed in granulocyte tibiofemoral joint primary oocyte secondary oocyte zygote large intestine colon left colon bone marrow trachea More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding protease binding integrin binding calcium-dependent protein binding Cellular component anchored component of membrane extracellular exosome membrane specific granule membrane plasma membrane secretory granule membrane plasma membrane raft tertiary granule membrane extracellular region lamellipodium cell projection membrane raft Biological process blood coagulation leukocyte migration neutrophil degranulation cell adhesion leukocyte cell-cell adhesion regulation of endocytosis positive regulation of superoxide anion generation protein localization to cell surface positive regulation of neutrophil degranulation cell-cell junction maintenance neutrophil extravasation cell-cell adhesion via plasma-membrane adhesion molecules neutrophil migration regulation of integrin-mediated signaling pathway immune system process innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57126 68891 Ensembl ENSG00000204936 ENSMUSG00000052212 UniProt Q8N6Q3 Q8R2S8 RefSeq (mRNA) NM_020406 NM_026862 RefSeq (protein) NP_065139 NP_081138 Location (UCSC) Chr 19: 43.35 – 43.36 Mb Chr 7: 24.44 – 24.46 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

NB1, a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia (Lalezari et al., 1971). [supplied by OMIM]

See also

• Cluster of differentiation

Further reading

• Stroncek D (2003). "Neutrophil-specific antigen HNA-2a (NB1, CD177): serology, biochemistry, and molecular biology". Vox Sang. 83 (Suppl 1): 359–61. doi:10.1111/j.1423-0410.2002.tb05334.x. PMID 12617169. S2CID 36683379.
• Pahl HL (2003). "PRV-1 mRNA expression and other molecular markers in polycythemia rubra vera". Curr. Hematol. Rep. 2 (3): 231–6. PMID 12901344.
• Kralovics R, Skoda RC (2005). "Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders". Blood Rev. 19 (1): 1–13. doi:10.1016/j.blre.2004.02.002. PMID 15572213.
• Goldschmeding R, van Dalen CM, Faber N, et al. (1992). "Further characterization of the NB 1 antigen as a variably expressed 56-62 kD GPI-linked glycoprotein of plasma membranes and specific granules of neutrophils". Br. J. Haematol. 81 (3): 336–45. doi:10.1111/j.1365-2141.1992.tb08237.x. PMID 1382544. S2CID 11604830.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Stroncek DF, Herr GP, Plachta LB (1994). "Neutrophil-specific antigen NB1 inhibits neutrophil-endothelial cell interactions". J. Lab. Clin. Med. 123 (2): 247–55. PMID 8301201.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Kissel K, Santoso S, Hofmann C, et al. (2001). "Molecular basis of the neutrophil glycoprotein NB1 (CD177) involved in the pathogenesis of immune neutropenias and transfusion reactions". Eur. J. Immunol. 31 (5): 1301–9. doi:10.1002/1521-4141(200105)31:5<1301::AID-IMMU1301>3.0.CO;2-J. PMID 11465086. S2CID 33769082.
• Bettinotti MP, Olsen A, Stroncek D (2002). "The use of bioinformatics to identify the genomic structure of the gene that encodes neutrophil antigen NB1, CD177". Clin. Immunol. 102 (2): 138–44. doi:10.1006/clim.2001.5154. PMID 11846455.
• Kissel K, Scheffler S, Kerowgan M, Bux J (2002). "Molecular basis of NB1 (HNA-2a, CD177) deficiency". Blood. 99 (11): 4231–3. doi:10.1182/blood.V99.11.4231. PMID 12010833.
• Klippel S, Strunck E, Busse CE, et al. (2002). "Biochemical characterization of PRV-1, a novel hematopoietic cell surface receptor, which is overexpressed in polycythemia rubra vera". Blood. 100 (7): 2441–8. doi:10.1182/blood-2002-03-0949. PMID 12239154.
• Teofili L, Martini M, Luongo M, et al. (2002). "Overexpression of the polycythemia rubra vera-1 gene in essential thrombocythemia". J. Clin. Oncol. 20 (20): 4249–54. doi:10.1200/JCO.2002.11.507. PMID 12377969.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Najfeld V, Fuchs S, Merando P, et al. (2003). "Fluorescence in situ hybridization analysis of the PRV-1 gene in polycythemia vera: implications for its role in diagnosis and pathogenesis". Exp. Hematol. 31 (2): 118–21. doi:10.1016/S0301-472X(02)01032-9. PMID 12591276.
• Wolff J, Brendel C, Fink L, et al. (2003). "Lack of NB1 GP (CD177/HNA-2a) gene transcription in NB1 GP- neutrophils from NB1 GP-expressing individuals and association of low expression with NB1 gene polymorphisms". Blood. 102 (2): 731–3. doi:10.1182/blood-2002-09-2831. PMID 12623849.
• Johansson P, Andréasson B, Safai-Kutti S, et al. (2003). "The presence of a significant association between elevated PRV-1 mRNA expression and low plasma erythropoietin concentration in essential thrombocythaemia". Eur. J. Haematol. 70 (6): 358–62. doi:10.1034/j.1600-0609.2003.00079.x. PMID 12756017. S2CID 13222207.

External links

• CD177+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CD177 genome location and CD177 gene details page in the UCSC Genome Browser.