CXCR6

C-X-C chemokine receptor type 6 is a protein that in humans is encoded by the CXCR6 gene. CXCR6 has also recently been designated CD186 (cluster of differentiation 186).

CXCR6
Identifiers
Aliases	CXCR6, BONZO, CD186, STRL33, TYMSTR, C-X-C motif chemokine receptor 6
External IDs	OMIM: 605163; MGI: 1934582; HomoloGene: 38197; GeneCards: CXCR6; OMA:CXCR6 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.31 Start 45,940,933 bp End 45,948,351 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 F4|9 74.57 cM Start 123,635,540 bp End 123,640,825 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen lymph node amniotic fluid gallbladder appendix blood tonsil mucosa of transverse colon granulocyte epithelium of colon Top expressed in thymus embryo embryo mesenteric lymph nodes spleen blastocyst blood subcutaneous adipose tissue right kidney duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function C-X-C chemokine receptor activity C-X-C chemokine binding G protein-coupled receptor activity chemokine receptor activity signal transducer activity coreceptor activity C-C chemokine receptor activity chemokine binding C-C chemokine binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane intracellular anatomical structure external side of plasma membrane Biological process viral genome replication chemotaxis chemokine-mediated signaling pathway G protein-coupled receptor signaling pathway inflammatory response signal transduction immune response positive regulation of cytosolic calcium ion concentration calcium-mediated signaling cell chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10663 80901 Ensembl ENSG00000172215 ENSMUSG00000048521 UniProt O00574 Q9EQ16 RefSeq (mRNA) NM_006564 NM_030712 RefSeq (protein) NP_006555 NP_109637 Location (UCSC) Chr 3: 45.94 – 45.95 Mb Chr 9: 123.64 – 123.64 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

CXCR6 has been identified as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4. It is a minor coreceptor for HIV-1, nearly all strains of which use CCR5 and/or CXCR4. Most SIV strains can use CXCR6 and recent evidence suggests that in monkeys that serve as the natural hosts of SIV, CXCR6 may be a major coreceptor. CXCR6 was previously known as "Bonzo" and "STRL33" in the HIV/SIV field.

Further reading

• Ruibal-Ares BH, Belmonte L, Baré PC, Parodi CM, Massud I, de Bracco MM (January 2004). "HIV-1 infection and chemokine receptor modulation". Current HIV Research. 2 (1): 39–50. doi:10.2174/1570162043484997. PMID 15053339.
• Loetscher M, Amara A, Oberlin E, Brass N, Legler D, Loetscher P, D'Apuzzo M, Meese E, Rousset D, Virelizier JL, Baggiolini M, Arenzana-Seisdedos F, Moser B (September 1997). "TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function". Current Biology. 7 (9): 652–60. Bibcode:1997CBio....7..652L. doi:10.1016/S0960-9822(06)00292-2. PMID 9285716.
• Hoffman TL, Stephens EB, Narayan O, Doms RW (September 1998). "HIV type I envelope determinants for use of the CCR2b, CCR3, STRL33, and APJ coreceptors". Proceedings of the National Academy of Sciences of the United States of America. 95 (19): 11360–5. Bibcode:1998PNAS...9511360H. doi:10.1073/pnas.95.19.11360. PMC 21647. PMID 9736741.
• Schramm B, Penn ML, Speck RF, Chan SY, De Clercq E, Schols D, Connor RI, Goldsmith MA (January 2000). "Viral entry through CXCR4 is a pathogenic factor and therapeutic target in human immunodeficiency virus type 1 disease". Journal of Virology. 74 (1): 184–92. doi:10.1128/JVI.74.1.184-192.2000. PMC 111527. PMID 10590105.
• Tscherning-Casper C, Vödrös D, Menu E, Aperia K, Fredriksson R, Dolcini G, Chaouat G, Barré-Sinoussi F, Albert J, Fenyö EM (May 2000). "Coreceptor usage of HIV-1 isolates representing different genetic subtypes obtained from pregnant Cameroonian women. European Network for In Utero Transmission of HIV-1". Journal of Acquired Immune Deficiency Syndromes. 24 (1): 1–9. doi:10.1097/00126334-200005010-00001. PMID 10877489.
• Ignatius R, Wei Y, Beaulieu S, Gettie A, Steinman RM, Pope M, Mojsov S (July 2000). "The immunodeficiency virus coreceptor, Bonzo/STRL33/TYMSTR, is expressed by macaque and human skin- and blood-derived dendritic cells". AIDS Research and Human Retroviruses. 16 (11): 1055–9. doi:10.1089/08892220050075318. PMID 10933620.
• Unutmaz D, Xiang W, Sunshine MJ, Campbell J, Butcher E, Littman DR (September 2000). "The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse". Journal of Immunology. 165 (6): 3284–92. doi:10.4049/jimmunol.165.6.3284. PMID 10975845. S2CID 2518260.
• Matloubian M, David A, Engel S, Ryan JE, Cyster JG (October 2000). "A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo". Nature Immunology. 1 (4): 298–304. doi:10.1038/79738. PMID 11017100. S2CID 22773861.
• Wilbanks A, Zondlo SC, Murphy K, Mak S, Soler D, Langdon P, Andrew DP, Wu L, Briskin M (April 2001). "Expression cloning of the STRL33/BONZO/TYMSTRligand reveals elements of CC, CXC, and CX3C chemokines". Journal of Immunology. 166 (8): 5145–54. doi:10.4049/jimmunol.166.8.5145. PMID 11290797.
• Lee B, Leslie G, Soilleux E, O'Doherty U, Baik S, Levroney E, Flummerfelt K, Swiggard W, Coleman N, Malim M, Doms RW (December 2001). "cis Expression of DC-SIGN allows for more efficient entry of human and simian immunodeficiency viruses via CD4 and a coreceptor". Journal of Virology. 75 (24): 12028–38. doi:10.1128/JVI.75.24.12028-12038.2001. PMC 116098. PMID 11711593.
• Calabresi PA, Yun SH, Allie R, Whartenby KA (June 2002). "Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNgamma-producing effector cells". Journal of Neuroimmunology. 127 (1–2): 96–105. doi:10.1016/S0165-5728(02)00106-6. PMID 12044980. S2CID 46059196.
• Kim CH, Johnston B, Butcher EC (July 2002). "Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity". Blood. 100 (1): 11–6. doi:10.1182/blood-2001-12-0196. PMID 12070001. S2CID 37076470.
• Duggal P, An P, Beaty TH, Strathdee SA, Farzadegan H, Markham RB, Johnson L, O'Brien SJ, Vlahov D, Winkler CA (June 2003). "Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans". Genes and Immunity. 4 (4): 245–50. doi:10.1038/sj.gene.6363950. PMID 12761559. S2CID 6657058.
• Koprak S, Matheravidathu S, Springer M, Gould S, Dumont FJ (May 2003). "Down-regulation of cell surface CXCR6 expression during T cell activation is predominantly mediated by calcineurin". Cellular Immunology. 223 (1): 1–12. doi:10.1016/S0008-8749(03)00130-8. PMID 12914753.
• Shimaoka T, Nakayama T, Fukumoto N, Kume N, Takahashi S, Yamaguchi J, Minami M, Hayashida K, Kita T, Ohsumi J, Yoshie O, Yonehara S (February 2004). "Cell surface-anchored SR-PSOX/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6-expressing cells". Journal of Leukocyte Biology. 75 (2): 267–74. doi:10.1189/jlb.1003465. PMID 14634054. S2CID 18245723.

External links

• "Chemokine Receptors: CXCR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• Human CXCR6 genome location and CXCR6 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.