CCR1

CCR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Y5D
Identifiers
Aliases	CCR1, CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1, C-C motif chemokine receptor 1
External IDs	OMIM: 601159; MGI: 104618; HomoloGene: 20344; GeneCards: CCR1; OMA:CCR1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	46,208,313 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	123,768,729 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; periodontal fiber; ; buccal mucosa cell; ; appendix; ; spleen; ; decidua; ; bone marrow; ; trabecular bone;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; tibiofemoral joint; ; blood; ; ankle; ; body of femur; ; spleen; ; ankle joint; ; lumbar subsegment of spinal cord; ; duodenum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	C-C chemokine binding; G protein-coupled receptor activity; chemokine (C-C motif) ligand 5 binding; signal transducer activity; chemokine (C-C motif) ligand 7 binding; protein binding; chemokine receptor activity; C-C chemokine receptor activity; phosphatidylinositol phospholipase C activity; chemokine binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; external side of plasma membrane; cytoplasm;
Biological process	negative regulation of bone mineralization; positive regulation of cell migration; positive regulation of cytosolic calcium ion concentration; chemokine-mediated signaling pathway; cell-cell signaling; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; positive regulation of monocyte chemotaxis; cellular calcium ion homeostasis; positive regulation of osteoclast differentiation; dendritic cell chemotaxis; negative regulation of gene expression; chemotaxis; cell surface receptor signaling pathway; cell adhesion; response to wounding; immune response; positive regulation of ERK1 and ERK2 cascade; inflammatory response; calcium ion transport; signal transduction; exocytosis; positive regulation of calcium ion transport; G protein-coupled receptor signaling pathway; cytokine-mediated signaling pathway; calcium-mediated signaling; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	1230
	12768
	ENSG00000163823
	ENSMUSG00000025804
	P32246
	P51675
	NM_001295
	NM_009912
	NP_001286
	NP_034042
	Wikidata
View/Edit Human	View/Edit Mouse

C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene.^[5]

CCR1 has also recently been designated CD191 (cluster of differentiation 191).

Function

This gene encodes a member of the beta chemokine receptor family, which belongs to G protein-coupled receptors. The ligands of this receptor include CCL3 (or MIP-1 alpha), CCL5 (or RANTES), CCL7 (or MCP-3), and CCL23 (or MPIF-1). Chemokines and their receptors, which mediate signal transduction, are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CXCR1, are found to form a gene cluster on chromosome 3p.^[6]

Interactions

CCR1 has been shown to interact with CCL5.^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163823 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025804 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Neote K, DiGregorio D, Mak JY, Horuk R, Schall TJ (February 1993). "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor". Cell. 72 (3): 415–25. doi:10.1016/0092-8674(93)90118-A. PMID 7679328. S2CID 38479816.
^ "Entrez Gene: CCR1 chemokine (C-C motif) receptor 1".
^ Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J (July 2001). "Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils". European Journal of Immunology. 31 (7): 2170–8. doi:10.1002/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D. PMID 11449371.
^ Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, Zwahlen C, Trkola A, Marchant D, Clapham PR, Wells TN (April 2001). "The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity". The Journal of Biological Chemistry. 276 (14): 10620–6. doi:10.1074/jbc.M010867200. PMID 11116158.

External links

Human CCR1 genome location and CCR1 gene details page in the UCSC Genome Browser.
"Chemokine Receptors: CCR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2008-06-07. Retrieved 2008-11-25.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163823 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025804 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7679328-5] Neote K, DiGregorio D, Mak JY, Horuk R, Schall TJ (February 1993). "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor". Cell. 72 (3): 415–25. doi:10.1016/0092-8674(93)90118-A. PMID 7679328. S2CID 38479816.

[6] "Entrez Gene: CCR1 chemokine (C-C motif) receptor 1".

[pmid11449371-7] Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J (July 2001). "Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils". European Journal of Immunology. 31 (7): 2170–8. doi:10.1002/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D. PMID 11449371.

[pmid11116158-8] Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, Zwahlen C, Trkola A, Marchant D, Clapham PR, Wells TN (April 2001). "The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity". The Journal of Biological Chemistry. 276 (14): 10620–6. doi:10.1074/jbc.M010867200. PMID 11116158.

[5]

[1]

[2]

[3]

[4]

[6]

[7]

[8]

CCR1

Contents

Function

Interactions

References

Further reading

External links