Melanotransferrin

Melanotransferrin is a protein that in humans is encoded by the MFI2 gene. MFI2 has also recently been designated CD228 (cluster of differentiation 228).

MELTF
Identifiers
Aliases	MELTF, CD228, MAP97, MTF1, MTf, MFI2, melanotransferrin
External IDs	OMIM: 155750; MGI: 1353421; HomoloGene: 4335; GeneCards: MELTF; OMA:MELTF - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q29 Start 196,980,590 bp End 197,029,835 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 B2 Start 31,697,628 bp End 31,717,838 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia parotid gland decidua tendon of biceps brachii renal medulla parietal pleura cartilage tissue endothelial cell amniotic fluid germinal epithelium Top expressed in vestibular sensory epithelium stria vascularis epithelium of small intestine trachea migratory enteric neural crest cell utricle vestibular membrane of cochlear duct intercostal muscle ankle joint condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function iron ion binding protein binding metal ion binding Cellular component cell surface anchored component of plasma membrane anchored component of membrane integral component of plasma membrane extracellular exosome membrane extracellular region extracellular space plasma membrane endoplasmic reticulum lumen Biological process positive regulation of extracellular matrix disassembly iron ion homeostasis negative regulation of substrate adhesion-dependent cell spreading regulation of cell population proliferation positive regulation of plasminogen activation ion transport regulation of cell growth C-terminal protein lipidation post-translational protein modification transport iron ion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4241 30060 Ensembl ENSG00000163975 ENSMUSG00000022780 UniProt P08582 Q9R0R1 RefSeq (mRNA) NM_005929 NM_033316 NM_013900 RefSeq (protein) NP_005920 NP_201573 NP_038928 Location (UCSC) Chr 3: 196.98 – 197.03 Mb Chr 16: 31.7 – 31.72 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. It is part of neural crest tissue, often present in melanotic neuroectodermal tumor of infancy.

Further reading

• Suryo Rahmanto Y, Dunn LL, Richardson DR (2007). "The melanoma tumor antigen, melanotransferrin (p97): a 25-year hallmark--from iron metabolism to tumorigenesis". Oncogene. 26 (42): 6113–24. doi:10.1038/sj.onc.1210442. PMID 17452986. S2CID 35884470.
• Baker EN, Baker HM, Smith CA, et al. (1992). "Human melanotransferrin (p97) has only one functional iron-binding site". FEBS Lett. 298 (2–3): 215–8. Bibcode:1992FEBSL.298..215B. doi:10.1016/0014-5793(92)80060-T. PMID 1544447. S2CID 21022972.
• Garratt RC, Jhotí H (1992). "A molecular model for the tumour-associated antigen, p97, suggests a Zn-binding function". FEBS Lett. 305 (1): 55–61. Bibcode:1992FEBSL.305...55G. doi:10.1016/0014-5793(92)80654-Y. PMID 1633859. S2CID 23569786.
• Rose TM, Plowman GD, Teplow DB, et al. (1986). "Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence" (PDF). Proc. Natl. Acad. Sci. U.S.A. 83 (5): 1261–5. Bibcode:1986PNAS...83.1261R. doi:10.1073/pnas.83.5.1261. PMC 323055. PMID 2419904.
• Furukawa KS, Furukawa K, Real FX, et al. (1989). "A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97". J. Exp. Med. 169 (2): 585–90. doi:10.1084/jem.169.2.585. PMC 2189208. PMID 2463331.
• Sciot R, de Vos R, van Eyken P, et al. (1989). "In situ localization of melanotransferrin (melanoma-associated antigen P97) in human liver. A light- and electronmicroscopic immunohistochemical study". Liver. 9 (2): 110–9. doi:10.1111/j.1600-0676.1989.tb00387.x. PMID 2540389.
• Seligman PA, Butler CD, Massey EJ, et al. (1986). "The p97 antigen is mapped to the q24-qter region of chromosome 3; the same region as the transferrin receptor". Am. J. Hum. Genet. 38 (4): 540–8. PMC 1684788. PMID 3010712.
• Le Beau MM, Diaz MO, Plowman GD, et al. (1986). "Chromosomal sublocalization of the human p97 melanoma antigen". Hum. Genet. 72 (4): 294–6. doi:10.1007/BF00290951. PMID 3754536. S2CID 38961040.
• Plowman GD, Brown JP, Enns CA, et al. (1983). "Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3". Nature. 303 (5912): 70–2. Bibcode:1983Natur.303...70P. doi:10.1038/303070a0. PMID 6843660. S2CID 4332107.
• Kennard ML, Richardson DR, Gabathuler R, et al. (1995). "A novel iron uptake mechanism mediated by GPI-anchored human p97". EMBO J. 14 (17): 4178–86. doi:10.1002/j.1460-2075.1995.tb00091.x. PMC 394500. PMID 7556058.
• Food MR, Rothenberger S, Gabathuler R, et al. (1994). "Transport and expression in human melanomas of a transferrin-like glycosylphosphatidylinositol-anchored protein". J. Biol. Chem. 269 (4): 3034–40. doi:10.1016/S0021-9258(17)42043-6. PMID 8300636.
• Rothenberger S, Food MR, Gabathuler R, et al. (1996). "Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endothelium". Brain Res. 712 (1): 117–21. doi:10.1016/0006-8993(96)88505-2. PMID 8705293. S2CID 45470799.
• Chi DD, Merchant RE, Rand R, et al. (1997). "Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas". Am. J. Pathol. 150 (6): 2143–52. PMC 1858329. PMID 9176405.
• Richardson DR (2000). "The role of the membrane-bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell". Eur. J. Biochem. 267 (5): 1290–8. doi:10.1046/j.1432-1327.2000.01079.x. PMID 10691965.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
• Sekyere E, Food MR, Richardson DR (2002). "A second melanotransferrin gene (MTf2) and a novel protein isoform: explanation for the membrane-bound and soluble forms of melanotransferrin?". FEBS Lett. 512 (1–3): 350–2. Bibcode:2002FEBSL.512..350S. doi:10.1016/S0014-5793(02)02248-2. PMID 11852110. S2CID 38104056.
• Food MR, Sekyere EO, Richardson DR (2002). "The soluble form of the membrane-bound transferrin homologue, melanotransferrin, inefficiently donates iron to cells via nonspecific internalization and degradation of the protein". Eur. J. Biochem. 269 (18): 4435–45. doi:10.1046/j.1432-1033.2002.03140.x. PMID 12230555.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Guo J, Wen DR, Huang RR, et al. (2003). "Detection of multiple melanoma-associated markers in melanoma cell lines by RT in situ PCR". Exp. Mol. Pathol. 74 (2): 140–7. doi:10.1016/S0014-4800(03)00012-1. PMID 12710945.

External links

• MFI2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.