CD8+ cell noncytotoxic anti-HIV response appears to be an anti-HIV innate immune response because it can be observed in vitro with CD8+ cells from unexposed and uninfected healthy individuals.[1]
The presence of a CD8+ cell noncytotoxic anti-HIV response (CNAR) was first reported in 1986 by researchers in the laboratory of Dr. Jay Levy at the University of California San Francisco (UCSF).[2] It was recognized that CD8+ cells from HIV-infected individuals can suppress HIV replication without directly killing the infected cells.[3]
CNAR appears to be mediated by a CD8+ cell anti-HIV factor (CAF) that has not yet been identified.[4] Other soluble factors can act against HIV including the β-chemokines.[5]
References
edit- ^ Levy, Jay A. (2007), HIV and the pathogenesis of AIDS (3 ed.), Wiley-Blackwell, p. 209, ISBN 978-1-55581-393-2
- ^ Walker CM, Moody DJ, Stites DP, Levy JA (1986). "CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication". Science. 234 (4783): 1563–6. Bibcode:1986Sci...234.1563W. doi:10.1126/science.2431484. PMID 2431484.
- ^ Barker, Edward; Bossart, Katharine N.; Levy, Jay A. (1998-02-17). "Primary CD8+cells from HIV-infected individuals can suppress productive infection of macrophages independent of β-chemokines". Proceedings of the National Academy of Sciences. 95 (4). Proceedings of the National Academy of Sciences: 1725–1729. doi:10.1073/pnas.95.4.1725. ISSN 0027-8424. PMC 19166.
- ^ Levy, JA (2003). "The search for the CD8+ cell anti-HIV factor (CAF)". Trends Immunol. 24 (12): 628–32. doi:10.1016/j.it.2003.10.005. PMID 14644135.
- ^ Cocchi, Fiorenza; DeVico, Anthony L.; Garzino-Demo, Alfredo; Arya, Suresh K.; Gallo, Robert C.; Lusso, Paolo (1995). "Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8+ T Cells". Science. 270 (5243): 1811–1815. Bibcode:1995Sci...270.1811C. doi:10.1126/science.270.5243.1811. PMID 8525373. S2CID 84062618.
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