Cdc42 effector protein 4 is a protein that in humans is encoded by the CDC42EP4 gene .[ 5] [ 6] [ 7]
The product of this gene is a member of the CDC42 -binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton . This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP -dependent manner. When overexpressed in fibroblasts , this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000179604 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041598 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Hirsch DS, Pirone DM, Burbelo PD (Mar 2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes" . J Biol Chem . 276 (2): 875–83. doi :10.1074/jbc.M007039200 PMID 11035016 . ^ Joberty G, Perlungher RR, Macara IG (Feb 2000). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins" . Mol Cell Biol . 19 (10): 6585–97. doi :10.1128/MCB.19.10.6585 . PMC 84628 PMID 10490598 . ^ a b "Entrez Gene: CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4" .
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