Cell division cycle-associated protein 7 is a protein that in humans is encoded by the CDCA7 gene .[ 5] [ 6] [ 7]
This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000144354 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055612 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Prescott JE, Osthus RC, Lee LA, Lewis BC, Shim H, Barrett JF, Guo Q, Hawkins AL, Griffin CA, Dang CV (Dec 2001). "A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation" . J Biol Chem . 276 (51): 48276–84. doi :10.1074/jbc.M107357200 PMID 11598121 . ^ Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets . 1 (1): 73–83. doi :10.2174/1568009013334241 . PMID 12188893 . ^ a b "Entrez Gene: CDCA7 cell division cycle associated 7" .
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