CDFS may refer to:
- CDfs, a Linux virtual file system
- cdfs, a Plan 9 user-space program, is also covered by the above article
- Compact Disc File System, or ISO 9660
- CDFS, an acronym in electrical engineering that has the meaning of inquiring the status of the Schematic completion from the DCM entity (Cand Dracului Faci Schema)
- Chandra Deep Field South, an astronomical survey in the constellation Fornax