CDP-archaeol synthase (EC 2.7.7.67, CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase, CTP:2,3-GG-GP ether cytidylyltransferase, CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase) is an enzyme with systematic name CTP:2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phosphate cytidylyltransferase.[1][2] This enzyme catalyses the following chemical reaction

CDP-archaeol synthase
Identifiers
EC no.2.7.7.67
CAS no.329791-09-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins
CTP + 2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phosphate diphosphate + CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol

This enzyme catalyses one of the steps in the biosynthesis of polar lipids in Archaea.

References

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  1. ^ Morii H, Nishihara M, Koga Y (November 2000). "CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus". The Journal of Biological Chemistry. 275 (47): 36568–74. doi:10.1074/jbc.m005925200. PMID 10960477.
  2. ^ Morii H, Koga Y (February 2003). "CDP-2,3-Di-O-geranylgeranyl-sn-glycerol:L-serine O-archaetidyltransferase (archaetidylserine synthase) in the methanogenic archaeon Methanothermobacter thermautotrophicus". Journal of Bacteriology. 185 (4): 1181–9. doi:10.1128/jb.185.4.1181-1189.2003. PMC 142863. PMID 12562787.
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