CUGBP2

CUGBP, Elav-like family member 2, also known as Etr-3 is a protein that in humans is encoded by the CELF2 gene.

CELF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MY7, 2MY8, 4LJM, 4LMZ, 4TLQ
Identifiers
Aliases	CELF2, BRUNOL3, CUGBP2, ETR-3, ETR3, NAPOR, CELF-2, CUG-BP2, CUGBP, Elav-like family member 2, CUGBP Elav-like family member 2, DEE97
External IDs	OMIM: 602538; MGI: 1338822; HomoloGene: 4783; GeneCards: CELF2; OMA:CELF2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10p14 Start 10,798,397 bp End 11,336,675 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 A1 Start 6,539,694 bp End 7,509,563 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Region I of hippocampus proper orbitofrontal cortex entorhinal cortex trabecular bone middle temporal gyrus postcentral gyrus Brodmann area 46 lateral nuclear group of thalamus Brodmann area 23 germinal epithelium Top expressed in Rostral migratory stream lateral septal nucleus olfactory tubercle nucleus accumbens anterior amygdaloid area subiculum barrel cortex ganglionic eminence olfactory bulb medial dorsal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding RNA binding pre-mRNA binding mRNA binding Cellular component cytoplasm nucleus ribonucleoprotein complex Biological process mRNA processing RNA processing regulation of heart contraction mRNA splice site selection regulation of alternative mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10659 14007 Ensembl ENSG00000048740 ENSMUSG00000002107 UniProt O95319 Q9Z0H4 RefSeq (mRNA) NM_001025076 NM_001025077 NM_001083591 NM_006561 NM_001326317 NM_001326318 NM_001326319 NM_001326320 NM_001326321 NM_001326323 NM_001326324 NM_001326325 NM_001326326 NM_001326327 NM_001326328 NM_001326329 NM_001326330 NM_001326331 NM_001326332 NM_001326333 NM_001326334 NM_001326335 NM_001326336 NM_001326337 NM_001326338 NM_001326339 NM_001326340 NM_001326341 NM_001326342 NM_001326343 NM_001326344 NM_001326345 NM_001326346 NM_001326347 NM_001326348 NM_001326349 NM_001394502 NM_001394513 NM_001394517 NM_001394518 NM_001394519 NM_001110228 NM_001110229 NM_001110230 NM_001110231 NM_001110232 NM_001160292 NM_001160293 NM_010160 NM_183219 NM_001310447 NM_001347094 RefSeq (protein) NP_001020247 NP_001020248 NP_001077060 NP_001313246 NP_001313247 NP_001313248 NP_001313249 NP_001313250 NP_001313252 NP_001313253 NP_001313254 NP_001313255 NP_001313256 NP_001313257 NP_001313258 NP_001313259 NP_001313260 NP_001313261 NP_001313262 NP_001313263 NP_001313264 NP_001313265 NP_001313266 NP_001313267 NP_001313268 NP_001313269 NP_001313270 NP_001313271 NP_001313272 NP_001313273 NP_001313274 NP_001313275 NP_001313276 NP_001313277 NP_001313278 NP_006552 NP_001103698 NP_001103699 NP_001103700 NP_001103701 NP_001103702 NP_001153764 NP_001153765 NP_001297376 NP_001334023 NP_034290 NP_001393762 NP_001393763 NP_001393764 NP_001393770 NP_001393771 NP_001393772 NP_001393773 NP_001393774 NP_001393775 NP_001393776 NP_001393777 NP_001393778 NP_001393779 NP_001393780 NP_001393781 NP_001393783 NP_001393784 NP_001393787 NP_001393846 NP_001393847 NP_001393848 NP_001393849 NP_001393850 NP_001393851 NP_001393852 NP_001393853 NP_001393854 NP_001393855 NP_001393856 NP_001393857 NP_001393858 NP_001393859 NP_001393860 NP_001393861 NP_001393862 NP_001393863 NP_001393871 NP_001393872 NP_001393873 NP_001393874 NP_001393875 NP_001393876 NP_001393877 NP_001393878 NP_001393879 NP_001393880 NP_001393881 NP_001393882 NP_001393883 NP_001393884 NP_001393885 NP_001393886 NP_001393887 NP_001393888 NP_001393889 NP_001393890 NP_001393891 NP_001393892 NP_001393893 NP_001393894 NP_001393895 NP_001393896 NP_001393897 NP_001393898 NP_001393899 NP_001393900 NP_001393901 NP_001393902 NP_001393903 NP_001393904 NP_001393905 NP_001393906 NP_001393907 NP_001393908 NP_001393909 NP_001393910 NP_001393911 Location (UCSC) Chr 10: 10.8 – 11.34 Mb Chr 2: 6.54 – 7.51 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Members of the CELF/BRUNOL protein family are RNA-binding proteins and contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms.

Interactions

CUGBP2 has been shown to interact with A1CF.

External links

• Human CELF2 genome location and CELF2 gene details page in the UCSC Genome Browser.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Choi DK, Ito T, Tsukahara F, et al. (1999). "Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein". Gene. 237 (1): 135–42. doi:10.1016/S0378-1119(99)00312-1. PMID 10524244.
• Good PJ, Chen Q, Warner SJ, Herring DC (2000). "A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator". J. Biol. Chem. 275 (37): 28583–92. doi:10.1074/jbc.M003083200. PMID 10893231.
• Ladd AN, Charlet N, Cooper TA (2001). "The CELF Family of RNA Binding Proteins Is Implicated in Cell-Specific and Developmentally Regulated Alternative Splicing". Mol. Cell. Biol. 21 (4): 1285–96. doi:10.1128/MCB.21.4.1285-1296.2001. PMC 99581. PMID 11158314.
• Li D, Bachinski LL, Roberts R (2001). "Genomic organization and isoform-specific tissue expression of human NAPOR (CUGBP2) as a candidate gene for familial arrhythmogenic right ventricular dysplasia". Genomics. 74 (3): 396–401. doi:10.1006/geno.2001.6558. PMID 11414768.
• Anant S, Henderson JO, Mukhopadhyay D, et al. (2002). "Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor". J. Biol. Chem. 276 (50): 47338–51. doi:10.1074/jbc.M104911200. PMID 11577082.
• Lichtner P, Attié-Bitach T, Schuffenhauer S, et al. (2003). "Expression and mutation analysis of BRUNOL3, a candidate gene for heart and thymus developmental defects associated with partial monosomy 10p". J. Mol. Med. 80 (7): 431–42. doi:10.1007/s00109-002-0331-9. PMID 12110949. S2CID 24098272.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mukhopadhyay D, Houchen CW, Kennedy S, et al. (2003). "Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2". Mol. Cell. 11 (1): 113–26. doi:10.1016/S1097-2765(03)00012-1. PMID 12535526.
• Singh G, Charlet-B N, Han J, Cooper TA (2004). "ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo". Nucleic Acids Res. 32 (3): 1232–41. doi:10.1093/nar/gkh275. PMC 373409. PMID 14973222.
• Mukhopadhyay D, Jung J, Murmu N, et al. (2004). "CUGBP2 plays a critical role in apoptosis of breast cancer cells in response to genotoxic injury". Ann. N. Y. Acad. Sci. 1010 (1): 504–9. Bibcode:2003NYASA1010..504M. doi:10.1196/annals.1299.093. PMID 15033780. S2CID 38581539.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Murmu N, Jung J, Mukhopadhyay D, et al. (2004). "Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E2 in radiation damage". Proc. Natl. Acad. Sci. U.S.A. 101 (38): 13873–8. Bibcode:2004PNAS..10113873M. doi:10.1073/pnas.0406066101. PMC 518846. PMID 15358864.
• Han J, Cooper TA (2005). "Identification of CELF splicing activation and repression domains in vivo". Nucleic Acids Res. 33 (9): 2769–80. doi:10.1093/nar/gki561. PMC 1126903. PMID 15894795.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Chen Z, Eggerman TL, Patterson AP (2007). "ApoB mRNA editing is mediated by a coordinated modulation of multiple apoB mRNA editing enzyme components". Am. J. Physiol. Gastrointest. Liver Physiol. 292 (1): G53–65. doi:10.1152/ajpgi.00118.2006. PMID 16920700.