Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 is a protein that in humans is encoded by the ARAP3 gene.[5][6][7]
This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its full-length nature has not been determined.[7]
References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000120318 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024451 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, Coadwell J, et al. (Jan 2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Mol Cell. 9 (1): 95–108. doi:10.1016/S1097-2765(02)00434-3. PMID 11804589.
- ^ Santy LC, Casanova JE (May 2002). "GTPase signaling: bridging the GAP between ARF and Rho". Curr Biol. 12 (10): R360–2. Bibcode:2002CBio...12.R360S. doi:10.1016/S0960-9822(02)00860-6. PMID 12015138. S2CID 15875666.
- ^ a b "Entrez Gene: CENTD3 centaurin, delta 3".
External links
edit- Human ARAP3 genome location and ARAP3 gene details page in the UCSC Genome Browser.
Further reading
edit- Raaijmakers JH, Deneubourg L, Rehmann H, De Koning J, Zhang Z, Krugmann S, et al. (2007). "The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner". Cell. Signal. 19 (6): 1249–57. doi:10.1016/j.cellsig.2006.12.015. hdl:1874/35664. PMID 17314030. S2CID 356352.
- Lu Q, Wei W, Kowalski PE, Chang AC, Cohen SN (2005). "EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin". Proc. Natl. Acad. Sci. U.S.A. 101 (49): 17246–51. doi:10.1073/pnas.0407794101. PMC 534609. PMID 15569923.
- I ST, Nie Z, Stewart A, Najdovska M, Hall NE, He H, et al. (2005). "ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner". J. Cell Sci. 117 (Pt 25): 6071–84. doi:10.1242/jcs.01526. PMID 15546919.
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Reinhard C, Schweikert M, Wieland FT, Nickel W (2003). "Functional reconstitution of COPI coat assembly and disassembly using chemically defined components". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8253–7. Bibcode:2003PNAS..100.8253R. doi:10.1073/pnas.1432391100. PMC 166215. PMID 12832619.
- Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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