CENTG3

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 is an enzyme that in humans is encoded by the AGAP3 gene.

AGAP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IHW
Identifiers
Aliases	AGAP3, AGAP-3, CENTG3, CRAG, MRIP-1, cnt-g3, ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
External IDs	OMIM: 616813; MGI: 2183446; HomoloGene: 23742; GeneCards: AGAP3; OMA:AGAP3 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q36.1 Start 151,085,831 bp End 151,144,436 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 A3 Start 24,657,175 bp End 24,707,045 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe Brodmann area 9 cingulate gyrus anterior cingulate cortex prefrontal cortex amygdala hypothalamus nucleus accumbens anterior pituitary Top expressed in superior frontal gyrus dentate gyrus of hippocampal formation granule cell primary visual cortex neural layer of retina ventricular zone lip muscle of thigh cerebellar cortex otic vesicle saccule More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding metal ion binding GTPase activator activity GTPase activity polyubiquitin modification-dependent protein binding Cellular component membrane nucleus cytoplasm cell periphery Biological process positive regulation of GTPase activity signal transduction cellular response to reactive oxygen species proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 116988 213990 Ensembl ENSG00000133612 ENSMUSG00000023353 UniProt Q96P47 Q86ST5 Q8VHH5 RefSeq (mRNA) NM_001042535 NM_001281300 NM_001308304 NM_001308305 NM_031946 NM_001350102 NM_001350103 NM_001350104 NM_001256431 NM_139153 NM_001359881 RefSeq (protein) NP_001036000 NP_001268229 NP_001295233 NP_001295234 NP_114152 NP_001337031 NP_001337032 NP_001337033 NP_001036000.1 NP_001295233.1 NP_001295234.1 n/a Location (UCSC) Chr 7: 151.09 – 151.14 Mb Chr 5: 24.66 – 24.71 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

External links

• Human AGAP3 genome location and AGAP3 gene details page in the UCSC Genome Browser.

Further reading

• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Qin Q, Inatome R, Hotta A, et al. (2006). "A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein". J. Cell Biol. 172 (4): 497–504. doi:10.1083/jcb.200505079. PMC 2063670. PMID 16461359.
• Meurer S, Pioch S, Wagner K, et al. (2005). "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase". J. Biol. Chem. 279 (47): 49346–49354. doi:10.1074/jbc.M410565200. PMID 15381706.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Surks HK, Richards CT, Mendelsohn ME (2004). "Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA". J. Biol. Chem. 278 (51): 51484–51493. doi:10.1074/jbc.M305622200. PMID 14506264.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–772. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Xia C, Ma W, Stafford LJ, et al. (2003). "GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins". Mol. Cell. Biol. 23 (7): 2476–2488. doi:10.1128/MCB.23.7.2476-2488.2003. PMC 150724. PMID 12640130.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.