CERS6

Ceramide synthase 6 is a protein that in humans is encoded by the CERS6 gene.

CERS6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X2M
Identifiers
Aliases	CERS6, CERS5, LASS6, ceramide synthase 6
External IDs	OMIM: 615336; MGI: 2442564; HomoloGene: 72228; GeneCards: CERS6; OMA:CERS6 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q24.3 Start 168,456,249 bp End 168,775,134 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 C2 Start 68,691,785 bp End 68,944,626 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in hair follicle corpus epididymis mucosa of sigmoid colon decidua jejunal mucosa ganglionic eminence orbitofrontal cortex middle temporal gyrus epithelium of bronchus bronchial epithelial cell Top expressed in zygote gastrula secondary oocyte epithelium of small intestine granulocyte decidua Gonadal ridge transitional epithelium of urinary bladder primary oocyte ileum More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding sphingosine N-acyltransferase activity DNA-binding transcription factor activity, RNA polymerase II-specific protein binding Cellular component integral component of membrane nuclear membrane endoplasmic reticulum membrane membrane nucleus endoplasmic reticulum Biological process lipid metabolism sphingolipid biosynthetic process ceramide biosynthetic process regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 253782 241447 Ensembl ENSG00000172292 ENSMUSG00000027035 UniProt Q6ZMG9 Q8C172 RefSeq (mRNA) NM_001256126 NM_203463 NM_172856 NM_001347161 RefSeq (protein) NP_001243055 NP_982288 NP_001334090 NP_766444 Location (UCSC) Chr 2: 168.46 – 168.78 Mb Chr 2: 68.69 – 68.94 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Senkal CE, Ponnusamy S, Bielawski J, Hannun YA, Ogretmen B (2010). "Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways". FASEB J. 24 (1): 296–308. doi:10.1096/fj.09-135087. PMC 2797032. PMID 19723703.