Centrin 2

Centrin-2 is a protein that in humans is encoded by the CETN2 gene. It belongs to the centrin family of proteins.

CETN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M39, 1ZMZ, 2A4J, 2GGM, 2K2I, 2OBH
Identifiers
Aliases	CETN2, CALT, CEN2, centrin 2
External IDs	OMIM: 300006; MGI: 1347085; HomoloGene: 55798; GeneCards: CETN2; OMA:CETN2 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq28 Start 152,826,994 bp End 152,830,757 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X A7.3|X 37.29 cM Start 71,957,138 bp End 71,962,017 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell right uterine tube mucosa of paranasal sinus caput epididymis germinal epithelium olfactory zone of nasal mucosa corpus epididymis epithelium of nasopharynx optic nerve tail of epididymis Top expressed in Epithelium of choroid plexus vestibular sensory epithelium atrioventricular valve endocardial cushion epithelium of lens median eminence condyle iris fossa retinal pigment epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heterotrimeric G-protein binding metal ion binding calcium ion binding G-protein beta/gamma-subunit complex binding microtubule binding protein binding Cellular component photoreceptor connecting cilium centriole cytoplasm nucleoplasm ciliary basal body cytosol nucleus XPC complex centrosome intracellular anatomical structure cilium cytoskeleton microtubule organizing center nuclear pore nuclear basket transcription export complex 2 nuclear envelope nuclear pore Biological process nucleotide-excision repair, DNA damage recognition cell cycle spermatogenesis cell division G2/M transition of mitotic cell cycle regulation of cytokinesis centriole replication cellular response to DNA damage stimulus global genome nucleotide-excision repair nucleotide-excision repair, preincision complex assembly DNA repair nucleotide-excision repair ciliary basal body-plasma membrane docking mitotic cell cycle regulation of G2/M transition of mitotic cell cycle mitotic cytokinesis regulation of centrosome duplication calcium-mediated signaling microtubule cytoskeleton organization nucleotide-excision repair, DNA duplex unwinding protein transport mRNA transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1069 26370 Ensembl ENSG00000147400 ENSMUSG00000031347 UniProt P41208 Q9R1K9 RefSeq (mRNA) NM_004344 NM_019405 RefSeq (protein) NP_004335 NP_062278 Location (UCSC) Chr X: 152.83 – 152.83 Mb Chr X: 71.96 – 71.96 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Centrin-2 belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that centrin-2 plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome.

Interactions

CETN2 has been shown to interact with XPC and SFI1.

External links

• Human CETN2 genome location and CETN2 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: P41208 (Centrin-2) at the PDBe-KB.

Further reading

• Lee VD, Huang B (1994). "Molecular cloning and centrosomal localization of human caltractin". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11039–43. Bibcode:1993PNAS...9011039L. doi:10.1073/pnas.90.23.11039. PMC 47917. PMID 8248209.
• Wolfrum U, Salisbury JL (1998). "Expression of centrin isoforms in the mammalian retina". Exp. Cell Res. 242 (1): 10–7. doi:10.1006/excr.1998.4038. PMID 9665797. S2CID 8459226.
• Durussel I, Blouquit Y, Middendorp S, et al. (2000). "Cation- and peptide-binding properties of human centrin 2". FEBS Lett. 472 (2–3): 208–12. doi:10.1016/S0014-5793(00)01452-6. PMID 10788612.
• Mallon AM, Platzer M, Bate R, et al. (2000). "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man". Genome Res. 10 (6): 758–75. doi:10.1101/gr.10.6.758. PMC 310879. PMID 10854409.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Araki M, Masutani C, Takemura M, et al. (2001). "Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair". J. Biol. Chem. 276 (22): 18665–72. doi:10.1074/jbc.M100855200. PMID 11279143.
• Salisbury JL, Suino KM, Busby R, Springett M (2003). "Centrin-2 is required for centriole duplication in mammalian cells". Curr. Biol. 12 (15): 1287–92. doi:10.1016/S0960-9822(02)01019-9. PMID 12176356.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Matei E, Miron S, Blouquit Y, et al. (2003). "C-terminal half of human centrin 2 behaves like a regulatory EF-hand domain". Biochemistry. 42 (6): 1439–50. doi:10.1021/bi0269714. PMID 12578356.
• Gavet O, Alvarez C, Gaspar P, Bornens M (2004). "Centrin4p, a novel mammalian centrin specifically expressed in ciliated cells". Mol. Biol. Cell. 14 (5): 1818–34. doi:10.1091/mbc.E02-11-0709. PMC 165080. PMID 12802058.
• Popescu A, Miron S, Blouquit Y, et al. (2003). "Xeroderma pigmentosum group C protein possesses a high affinity binding site to human centrin 2 and calmodulin". J. Biol. Chem. 278 (41): 40252–61. doi:10.1074/jbc.M302546200. PMID 12890685.
• Kilmartin JV (2003). "Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication". J. Cell Biol. 162 (7): 1211–21. doi:10.1083/jcb.200307064. PMC 2173958. PMID 14504268.
• Chang F, Re F, Sebastian S, et al. (2004). "HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes". Mol. Biol. Cell. 15 (4): 1793–801. doi:10.1091/mbc.E03-09-0691. PMC 379276. PMID 14767062.
• Tourbez M, Firanescu C, Yang A, et al. (2005). "Calcium-dependent self-assembly of human centrin 2". J. Biol. Chem. 279 (46): 47672–80. doi:10.1074/jbc.M404996200. PMID 15356003.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Nishi R, Okuda Y, Watanabe E, et al. (2005). "Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein". Mol. Cell. Biol. 25 (13): 5664–74. doi:10.1128/MCB.25.13.5664-5674.2005. PMC 1156980. PMID 15964821.