CHMP4B

Charged multivesicular body protein 4b is a protein that in humans is encoded by the CHMP4B gene.

CHMP4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3C3Q, 3UM3, 4ABM
Identifiers
Aliases	CHMP4B, C20orf178, CHMP4A, CTPP3, CTRCT31, SNF7, SNF7-2, Shax1, VPS32B, Vps32-2, dJ553F4.4, charged multivesicular body protein 4B
External IDs	OMIM: 610897; MGI: 1922858; HomoloGene: 57102; GeneCards: CHMP4B; OMA:CHMP4B - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20q11.22 Start 33,811,348 bp End 33,854,366 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 H1 Start 154,493,625 bp End 154,536,705 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum skin of arm tibialis anterior muscle nasal epithelium mucosa of transverse colon cartilage tissue cardiac muscle tissue of right atrium muscle layer of sigmoid colon gastric mucosa tibial arteries Top expressed in vestibular membrane of cochlear duct Ileal epithelium Epithelium of choroid plexus transitional epithelium of urinary bladder conjunctival fornix substantia nigra facial motor nucleus anterior horn of spinal cord iris motor neuron More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity protein binding identical protein binding cadherin binding Cellular component cytoplasm ESCRT III complex cytosol endosome membrane late endosome membrane cytoplasmic side of plasma membrane membrane coat extracellular exosome vesicle midbody nuclear envelope nucleus Biological process negative regulation of autophagosome assembly regulation of centrosome duplication viral life cycle nucleus organization maintenance of lens transparency multivesicular body assembly negative regulation of cell death regulation of mitotic spindle assembly autophagy endosomal transport posttranslational protein targeting to endoplasmic reticulum membrane ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway protein transport septum digestion after cytokinesis mitotic metaphase plate congression protein homooligomerization vacuolar transport negative regulation of neuron death nuclear membrane reassembly exit from mitosis mitotic cytokinesis regulation of autophagy membrane fission macroautophagy transport viral budding via host ESCRT complex midbody abscission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 128866 75608 Ensembl ENSG00000101421 ENSMUSG00000038467 UniProt Q9H444 Q9D8B3 RefSeq (mRNA) NM_176812 NM_029362 RefSeq (protein) NP_789782 NP_083638 Location (UCSC) Chr 20: 33.81 – 33.85 Mb Chr 2: 154.49 – 154.54 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

External links

• Human CHMP4A genome location and CHMP4A gene details page in the UCSC Genome Browser.
• Human CHMP4B genome location and CHMP4B gene details page in the UCSC Genome Browser.

Further reading

• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Katoh K, Shibata H, Suzuki H, et al. (2003). "The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting". J. Biol. Chem. 278 (40): 39104–13. doi:10.1074/jbc.M301604200. PMID 12860994.
• Strack B, Calistri A, Craig S, et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569. S2CID 10733770.
• von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570. S2CID 16894972.
• Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. Bibcode:2003PNAS..10012414M. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
• Peck JW, Bowden ET, Burbelo PD (2004). "Structure and function of human Vps20 and Snf7 proteins". Biochem. J. 377 (Pt 3): 693–700. doi:10.1042/BJ20031347. PMC 1223912. PMID 14583093.
• Sharma M, Pampinella F, Nemes C, et al. (2004). "Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes". J. Cell Biol. 164 (6): 923–33. doi:10.1083/jcb.200312018. PMC 2172283. PMID 15007060.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yorikawa C, Shibata H, Waguri S, et al. (2005). "Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting". Biochem. J. 387 (Pt 1): 17–26. doi:10.1042/BJ20041227. PMC 1134928. PMID 15511219.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.
• Usami Y, Popov S, Göttlinger HG (2007). "Potent Rescue of Human Immunodeficiency Virus Type 1 Late Domain Mutants by ALIX/AIP1 Depends on Its CHMP4 Binding Site". J. Virol. 81 (12): 6614–22. doi:10.1128/JVI.00314-07. PMC 1900090. PMID 17428861.
• Shiels A, Bennett TM, Knopf HL, et al. (2007). "CHMP4B, a Novel Gene for Autosomal Dominant Cataracts Linked to Chromosome 20q". Am. J. Hum. Genet. 81 (3): 596–606. doi:10.1086/519980. PMC 1950844. PMID 17701905.