CHST11

Carbohydrate sulfotransferase 11 is an enzyme that in humans is encoded by the CHST11 gene.

CHST11
Identifiers
Aliases	CHST11, C4ST, C4ST-1, C4ST1, HSA269537, carbohydrate (chondroitin 4) sulfotransferase 11, carbohydrate sulfotransferase 11, OCBMD
External IDs	OMIM: 610128; MGI: 1927166; HomoloGene: 56808; GeneCards: CHST11; OMA:CHST11 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q23.3 Start 104,455,295 bp End 104,762,014 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 C1 Start 82,821,332 bp End 83,031,734 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia blood cartilage tissue monocyte bone marrow cells ventricular zone granulocyte amniotic fluid trabecular bone internal globus pallidus Top expressed in cumulus cell molar fossa medial dorsal nucleus condyle vestibular membrane of cochlear duct substantia nigra subiculum median eminence arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity N-acetylgalactosamine 4-O-sulfotransferase activity N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity chondroitin 4-sulfotransferase activity Cellular component Golgi apparatus membrane Golgi membrane integral component of membrane Biological process embryonic skeletal system morphogenesis chondrocyte development embryonic digit morphogenesis negative regulation of apoptotic process negative regulation of transforming growth factor beta receptor signaling pathway post-embryonic development respiratory gaseous exchange by respiratory system cartilage development developmental growth regulation of cell population proliferation embryonic limb morphogenesis polysaccharide localization post-anal tail morphogenesis embryonic viscerocranium morphogenesis carbohydrate biosynthetic process chondroitin sulfate biosynthetic process chondroitin sulfate metabolic process carbohydrate metabolic process proteoglycan biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50515 58250 Ensembl ENSG00000171310 ENSMUSG00000034612 UniProt Q9NPF2 Q9JME2 RefSeq (mRNA) NM_018413 NM_001173982 NM_021439 RefSeq (protein) NP_001167453 NP_060883 NP_060883.1 NP_067414 Location (UCSC) Chr 12: 104.46 – 104.76 Mb Chr 10: 82.82 – 83.03 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Clinical relevance

Mutations in this gene have been associated to susceptibility for osteoarthritis.

External links

• Human CHST11 genome location and CHST11 gene details page in the UCSC Genome Browser.

Further reading

• Yamauchi S, Mita S, Matsubara T, Fukuta M, Habuchi H, Kimata K, Habuchi O (Mar 2000). "Molecular cloning and expression of chondroitin 4-sulfotransferase". The Journal of Biological Chemistry. 275 (12): 8975–81. doi:10.1074/jbc.275.12.8975. PMID 10722746.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Okuda T, Mita S, Yamauchi S, Matsubara T, Yagi F, Yamamori D, Fukuta M, Kuroiwa A, Matsuda Y, Habuchi O (Nov 2000). "Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase". Journal of Biochemistry. 128 (5): 763–70. doi:10.1093/oxfordjournals.jbchem.a022813. PMID 11056388.
• Mikami T, Mizumoto S, Kago N, Kitagawa H, Sugahara K (Sep 2003). "Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis". The Journal of Biological Chemistry. 278 (38): 36115–27. doi:10.1074/jbc.M306044200. PMID 12847091.
• Schmidt HH, Dyomin VG, Palanisamy N, Itoyama T, Nanjangud G, Pirc-Danoewinata H, Haas OA, Chaganti RS (Sep 2004). "Deregulation of the carbohydrate (chondroitin 4) sulfotransferase 11 (CHST11) gene in a B-cell chronic lymphocytic leukemia with a t(12;14)(q23;q32)". Oncogene. 23 (41): 6991–6. doi:10.1038/sj.onc.1207934. PMID 15273723.
• Yamada T, Ohtake S, Sato M, Habuchi O (Dec 2004). "Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues". The Biochemical Journal. 384 (Pt 3): 567–75. doi:10.1042/BJ20040965. PMC 1134142. PMID 15324304.
• Yusa A, Kitajima K, Habuchi O (May 2005). "N-linked oligosaccharides are required to produce and stabilize the active form of chondroitin 4-sulphotransferase-1". The Biochemical Journal. 388 (Pt 1): 115–21. doi:10.1042/BJ20041573. PMC 1186699. PMID 15628971.