CHST7

Carbohydrate sulfotransferase 7 is an enzyme that in humans is encoded by the CHST7 gene.

CHST7
Identifiers
Aliases	CHST7, C6ST-2, GST-5, carbohydrate sulfotransferase 7
External IDs	OMIM: 300375; MGI: 1891767; HomoloGene: 10531; GeneCards: CHST7; OMA:CHST7 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xp11.3 Start 46,573,765 bp End 46,598,496 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X A1.3 Start 19,925,799 bp End 19,963,760 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua left ovary right ovary right auricle stromal cell of endometrium testicle left ventricle canal of the cervix left coronary artery subcutaneous adipose tissue Top expressed in right kidney primary oocyte proximal tubule primitive streak interventricular septum secondary oocyte zygote endothelial cell of lymphatic vessel human kidney embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity N-acetylglucosamine 6-O-sulfotransferase activity chondroitin 6-sulfotransferase activity Cellular component integral component of membrane Golgi membrane Golgi apparatus membrane trans-Golgi network Biological process sulfur compound metabolic process chondroitin sulfate biosynthetic process N-acetylglucosamine metabolic process polysaccharide metabolic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56548 60322 Ensembl ENSG00000147119 ENSMUSG00000037347 UniProt Q9NS84 Q9EP78 RefSeq (mRNA) NM_019886 NM_021715 RefSeq (protein) NP_063939 NP_068361 Location (UCSC) Chr X: 46.57 – 46.6 Mb Chr X: 19.93 – 19.96 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene belongs to the sulfotransferase gene family. Sulfotransferases generate sulfated glycosaminoglycan (GAG) moieties during chondroitin sulfate biosynthesis. They create considerable structural diversity among chondroitin sulfates by transferring sulfate with remarkable specificity for the underlying oligosaccharide substrate. This gene product mainly transfers sulfate to N-acetylgalactosamine. The regulated expression of each member of this gene family may be an important determinant of sulfated GAGs expression and the associated function of chondroitin sulfates as regulators of many biologic processes. This gene is part of a gene cluster on chromosome Xp11.23.

External links

• Human CHST7 genome location and CHST7 gene details page in the UCSC Genome Browser.

Further reading

• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Thiselton DL, McDowall J, Brandau O, et al. (2002). "An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders". Genomics. 79 (4): 560–72. doi:10.1006/geno.2002.6733. PMID 11944989.
• Bhakta S, Bartes A, Bowman KG, et al. (2001). "Sulfation of N-acetylglucosamine by chondroitin 6-sulfotransferase 2 (GST-5)". J. Biol. Chem. 275 (51): 40226–34. doi:10.1074/jbc.M006414200. PMID 10956661.
• Uchimura K, Fasakhany F, Kadomatsu K, et al. (2000). "Diversity of N-acetylglucosamine-6-O-sulfotransferases: molecular cloning of a novel enzyme with different distribution and specificities". Biochem. Biophys. Res. Commun. 274 (2): 291–6. doi:10.1006/bbrc.2000.3141. PMID 10913333.
• Shilatifard A, Merkle RK, Helland DE, et al. (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine". J. Virol. 67 (2): 943–52. doi:10.1128/JVI.67.2.943-952.1993. PMC 237448. PMID 8419650.
• Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein". J. Virol. 66 (12): 6953–9. doi:10.1128/JVI.66.12.6953-6959.1992. PMC 240329. PMID 1433500.