CKS2

For the aerodrome using the TC LID, CKS2, see Kennisis Lake/Francis Water Aerodrome.

Cyclin-dependent kinases regulatory subunit 2 is a protein that in humans is encoded by the CKS2 gene.

CKS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CKS, 4Y72, 5HQ0, 4YC3
Identifiers
Aliases	CKS2, CKSHS2, CDC28 protein kinase regulatory subunit 2
External IDs	OMIM: 116901; MGI: 1913447; HomoloGene: 86883; GeneCards: CKS2; OMA:CKS2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q22.2 Start 89,311,195 bp End 89,316,703 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A5 Start 51,799,268 bp End 51,804,696 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone right testis left testis testicle ganglionic eminence sperm oocyte trabecular bone gonad mucosa of transverse colon Top expressed in morula zygote secondary oocyte primary oocyte embryo epiblast ventricular zone embryo yolk sac blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cyclin-dependent protein serine/threonine kinase regulator activity chromatin binding histone binding protein kinase binding cyclin-dependent protein serine/threonine kinase activator activity ubiquitin binding protein binding Cellular component SCF ubiquitin ligase complex cyclin-dependent protein kinase holoenzyme complex Biological process cell cycle meiosis I cell division regulation of mitotic cell cycle positive regulation of cyclin-dependent protein serine/threonine kinase activity cell population proliferation positive regulation of transcription, DNA-templated mitotic cell cycle phase transition regulation of transcription by RNA polymerase II regulation of cyclin-dependent protein serine/threonine kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1164 66197 Ensembl ENSG00000123975 ENSMUSG00000062248 UniProt P33552 P56390 RefSeq (mRNA) NM_001827 NM_025415 RefSeq (protein) NP_001818 NP_079691 Location (UCSC) Chr 9: 89.31 – 89.32 Mb Chr 13: 51.8 – 51.8 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein.

External links

• Human CKS2 genome location and CKS2 gene details page in the UCSC Genome Browser.

Further reading

• Parge HE, Arvai AS, Murtari DJ, et al. (1993). "Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control". Science. 262 (5132): 387–95. Bibcode:1993Sci...262..387P. doi:10.1126/science.8211159. PMID 8211159.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Le XF, Lammayot A, Gold D, et al. (2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". J. Biol. Chem. 280 (3): 2092–104. doi:10.1074/jbc.M403080200. PMID 15504738.
• Gorr IH, Boos D, Stemmann O (2005). "Mutual inhibition of separase and Cdk1 by two-step complex formation". Mol. Cell. 19 (1): 135–41. doi:10.1016/j.molcel.2005.05.022. PMID 15989971.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Rother K, Dengl M, Lorenz J, et al. (2007). "Gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 but not by the related proteins p63 or p73". FEBS Lett. 581 (6): 1166–72. doi:10.1016/j.febslet.2007.02.028. PMID 17336302. S2CID 6953397.
• Bertheau P, Turpin E, Rickman DS, et al. (2007). "Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen". PLOS Med. 4 (3): e90. doi:10.1371/journal.pmed.0040090. PMC 1831731. PMID 17388661.