CLDN22

Claudin-22 is a protein that in humans is encoded by the CLDN22 gene. It belongs to the group of claudins.

CLDN22
Identifiers
Aliases	CLDN22, CLDN21, claudin 22
External IDs	MGI: 1922927; HomoloGene: 129823; GeneCards: CLDN22; OMA:CLDN22 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q35.1 Start 183,318,100 bp End 183,320,276 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 B1.1 Start 48,277,517 bp End 48,278,511 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle olfactory zone of nasal mucosa minor salivary glands gonad granulocyte right lobe of liver apex of heart primary visual cortex endometrium ventricular zone Top expressed in parotid gland sciatic nerve otolith organ utricle lacrimal gland vestibular sensory epithelium blastocyst morula lumbar spinal ganglion vestibular membrane of cochlear duct More reference expression data BioGPS n/a
Gene ontology Molecular function structural molecule activity identical protein binding Cellular component plasma membrane integral component of membrane cell junction membrane bicellular tight junction Biological process calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53842 75677 Ensembl ENSG00000177300 ENSMUSG00000038064 UniProt Q8N7P3 Q9D7U6 RefSeq (mRNA) NM_001111319 NM_029383 RefSeq (protein) NP_001104789 NP_083659 Location (UCSC) Chr 4: 183.32 – 183.32 Mb Chr 8: 48.28 – 48.28 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

External links

• Human CLDN22 genome location and CLDN22 gene details page in the UCSC Genome Browser.

Further reading

• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
• Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
• Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
• Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159.
• Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502. S2CID 26473781.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Katoh M, Katoh M (2004). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". Int. J. Mol. Med. 11 (6): 683–9. doi:10.3892/ijmm.11.6.683. PMID 12736707.
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.