Claudin-9 is a protein that in humans is encoded by the CLDN9 gene.[5][6][7] It belongs to the group of claudins.

CLDN9
Identifiers
AliasesCLDN9, claudin 9, DFNB116
External IDsOMIM: 615799; MGI: 1913100; HomoloGene: 10656; GeneCards: CLDN9; OMA:CLDN9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020982

NM_020293

RefSeq (protein)

NP_066192

NP_064689

Location (UCSC)Chr 16: 3.01 – 3.01 MbChr 17: 23.9 – 23.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is expressed in the inner ear, olfactory epithelium, and anterior pituitary gland [8] and is involved in hearing.[9][10][11]


References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000213937Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066720Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Peacock RE, Keen TJ, Inglehearn CF (Mar 1998). "Analysis of a human gene homologous to rat ventral prostate.1 protein". Genomics. 46 (3): 443–9. doi:10.1006/geno.1997.5033. PMID 9441748.
  6. ^ Meertens L, Bertaux C, Cukierman L, Cormier E, Lavillette D, Cosset FL, Dragic T (Mar 2008). "The tight junction proteins claudin-1, -6, and -9 are entry cofactors for hepatitis C virus". J Virol. 82 (7): 3555–60. doi:10.1128/JVI.01977-07. PMC 2268462. PMID 18234789.
  7. ^ "Entrez Gene: CLDN9 claudin 9".
  8. ^ Higashi AY, Higashi T, Furuse K, Ozeki K, Furuse M, Chiba H (Nov 2021). "Claudin-9 constitutes tight junctions of folliclo-stellate cells in the anterior pituitary gland". Scientific Reports. 11 (1): 21642. Bibcode:2021NatSR..1121642H. doi:10.1038/s41598-021-01004-z. PMC 8568902. PMID 34737342.
  9. ^ Gene discovery reveals a critical protein's function in hearing
  10. ^ Nakano Y, Kim SH, Kim HM, Sanneman JD, Zhang Y, Smith RJ, Marcus DC, Wangemann P, Nessler RA, Bánfi B (Aug 2009). "A claudin-9-based ion permeability barrier is essential for hearing". PLOS Genetics. 5 (8): e1000610. doi:10.1371/journal.pgen.1000610. PMC 2720454. PMID 19696885.
  11. ^ Sineni CJ, Yildirim-Baylan M, Guo S, Camarena V, Wang G, Tokgoz-Yilmaz S, Duman D, Bademci G, Tekin M (Oct 2019). "A truncating CLDN9 variant if associated with autosomal recessive nonsyndromic hearing loss". Human Genetics. 138 (10): 1071–1075. doi:10.1007/s00439-019-02037-1. PMC 6745279. PMID 31175426.
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Further reading

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