CLK3 (gene)

Dual specificity protein kinase CLK3 is an enzyme that in humans is encoded by the CLK3 gene. The CLK3 gene encodes a serine/threonine type protein kinase with a non-conserved N-terminal domain. A long and short isoform (phclk3 and pclk3/152) result from alternative splicing and coexist in different tissues. Isoform phclk3/152 lacks the kinase domain.

CLK3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EU9, 2EXE, 2WU6, 2WU7, 3RAW
Identifiers
Aliases	CLK3, PHPHCLK3/152, CDC like kinase 3
External IDs	OMIM: 602990; MGI: 1098670; HomoloGene: 101534; GeneCards: CLK3; OMA:CLK3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q24.1 Start 74,598,500 bp End 74,645,414 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 B Start 57,657,907 bp End 57,673,143 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte left testis right testis monocyte anterior pituitary left lobe of thyroid gland mucosa of transverse colon skin of leg minor salivary glands skin of abdomen Top expressed in thymus granulocyte lip muscle of thigh aortic valve ascending aorta neural layer of retina fetal liver hematopoietic progenitor cell superior surface of tongue spermatid More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein serine/threonine kinase activity protein binding protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity ATP binding identical protein binding RNA binding Cellular component cytoplasm nuclear speck membrane nucleoplasm acrosomal vesicle intermediate filament cytoskeleton cytoplasmic vesicle nucleus Biological process phosphorylation protein phosphorylation regulation of RNA splicing protein autophosphorylation peptidyl-tyrosine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1198 102414 Ensembl ENSG00000179335 ENSMUSG00000032316 UniProt P49761 O35492 RefSeq (mRNA) NM_001130028 NM_001292 NM_003992 NM_007713 RefSeq (protein) NP_001123500 NP_003983 NP_031739 Location (UCSC) Chr 15: 74.6 – 74.65 Mb Chr 9: 57.66 – 57.67 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Duncan PI, Stojdl DF, Marius RM, et al. (1998). "The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing". Exp. Cell Res. 241 (2): 300–8. doi:10.1006/excr.1998.4083. PMID 9637771.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. hdl:10033/19756. PMID 17192257.

External links

• Clk dual-specificity kinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CLK3 genome location and CLK3 gene details page in the UCSC Genome Browser.