CNOT6L

CCR4-NOT transcription complex subunit 6 like is a protein that in humans is encoded by the CNOT6L gene. It is a paralog of CNOT6 and therefore a potential subunit of the CCR4-Not deadenylase complex.

CNOT6L
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3NGN, 3NGO, 3NGQ, 5DV2
Identifiers
Aliases	CNOT6L, CCR4b, CCR4-NOT transcription complex subunit 6 like
External IDs	OMIM: 618069; MGI: 2443154; HomoloGene: 100830; GeneCards: CNOT6L; OMA:CNOT6L - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q21.1 Start 77,713,387 bp End 77,819,615 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 E3 Start 96,218,192 bp End 96,312,030 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte mucosa of ileum superficial temporal artery tibialis anterior muscle bone marrow cells thymus corpus epididymis tonsil jejunal mucosa epithelium of colon Top expressed in hair follicle skin of external ear Rostral migratory stream secondary oocyte primary oocyte vas deferens utricle efferent ductule blood tibiofemoral joint More reference expression data BioGPS n/a
Gene ontology Molecular function poly(A)-specific ribonuclease activity metal ion binding protein binding nuclease activity exonuclease activity hydrolase activity 3'-5'-exoribonuclease activity Cellular component cytoplasm CCR4-NOT complex nucleus cytosol Biological process nuclear-transcribed mRNA poly(A) tail shortening regulation of transcription, DNA-templated RNA phosphodiester bond hydrolysis, exonucleolytic mRNA processing transcription, DNA-templated positive regulation of cytoplasmic mRNA processing body assembly mRNA destabilization positive regulation of cell population proliferation gene silencing regulation of translation nucleic acid phosphodiester bond hydrolysis nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 246175 231464 Ensembl ENSG00000138767 ENSMUSG00000034724 UniProt Q96LI5 Q8VEG6 RefSeq (mRNA) NM_001286790 NM_144571 NM_001365006 NM_001365007 NM_001285511 NM_001285514 NM_144910 NM_178854 RefSeq (protein) NP_001273719 NP_653172 NP_001351935 NP_001351936 NP_001272440 NP_001272443 NP_659159 NP_849185 Location (UCSC) Chr 4: 77.71 – 77.82 Mb Chr 5: 96.22 – 96.31 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Morita M, Suzuki T, Nakamura T, Yokoyama K, Miyasaka T, Yamamoto T (July 2007). "Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth". Mol. Cell. Biol. 27 (13): 4980–90. doi:10.1128/MCB.02304-06. PMC 1951489. PMID 17452450.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Wang H, Morita M, Yang X, Suzuki T, Yang W, Wang J, Ito K, Wang Q, Zhao C, Bartlam M, Yamamoto T, Rao Z (August 2010). "Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity". EMBO J. 29 (15): 2566–76. doi:10.1038/emboj.2010.152. PMC 2928688. PMID 20628353.
• Naylor MG, Weiss ST, Lange C (September 2010). "A Bayesian approach to genetic association studies with family-based designs". Genet. Epidemiol. 34 (6): 569–74. doi:10.1002/gepi.20513. PMC 3349938. PMID 20818722.
• Mittal S, Aslam A, Doidge R, Medica R, Winkler GS (March 2011). "The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence". Mol. Biol. Cell. 22 (6): 748–58. doi:10.1091/mbc.E10-11-0898. PMC 3057700. PMID 21233283.
• Zhou W, Thiery JP (June 2013). "Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1". J. Cell Sci. 126 (Pt 12): 2740–6. doi:10.1242/jcs.126367. PMID 23591815.
• Polesskaya A, Pinna G, Sassi Y, Vandamme M, Bigot A, Mouly V, Morozova N, Harel-Bellan A, Degerny C (February 2016). "Post-transcriptional modulation of interleukin 8 by CNOT6L regulates skeletal muscle differentiation". Biochim. Biophys. Acta. 1863 (2): 263–70. doi:10.1016/j.bbamcr.2015.11.018. PMID 26608607.
• Zhang Q, Yan D, Guo E, Ding B, Yang W, Liu R, Yamamoto T, Bartlam M (April 2016). "Structural basis for inhibition of the deadenylase activity of human CNOT6L". FEBS Lett. 590 (8): 1270–9. doi:10.1002/1873-3468.12160. PMID 27013054.
• Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, Yamamoto T, Sonenberg N (April 2019). "Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis". Proc. Natl. Acad. Sci. U.S.A. 116 (16): 7973–7981. doi:10.1073/pnas.1816023116. PMC 6475422. PMID 30926667.