CNPY2

CNPY2
Identifiers
Aliases	CNPY2, HP10390, MSAP, TMEM4, ZSIG9, canopy FGF signaling regulator 2
External IDs	OMIM: 605861; MGI: 1928477; HomoloGene: 40934; GeneCards: CNPY2; OMA:CNPY2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	56,316,119 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	128,163,422 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; stromal cell of endometrium; ; body of pancreas; ; right lobe of thyroid gland; ; right adrenal cortex; ; left adrenal cortex; ; left lobe of thyroid gland; ; right lobe of liver; ; right ovary; ; mucosa of transverse colon;
	Top expressed in
	medullary collecting duct; ; fossa; ; vas deferens; ; seminal vesicula; ; condyle; ; lacrimal gland; ; efferent ductule; ; primitive streak; ; Epithelium of choroid plexus; ; molar;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of plasma membrane; endoplasmic reticulum;
Biological process	negative regulation of gene expression; regulation of low-density lipoprotein particle clearance; tissue development; enzyme linked receptor protein signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10330
	56530
	ENSG00000257727
	ENSMUSG00000025381
	Q9Y2B0
	Q9QXT0
	NM_014255; NM_001190991
	NM_019953
	NP_001177920; NP_055070
	NP_064337
	Wikidata
View/Edit Human	View/Edit Mouse

Canopy FGF signaling regulator 2 is a protein that in humans is encoded by the CNPY2 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000257727 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025381 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Canopy FGF signaling regulator 2".

Bornhauser BC, Lindholm D (June 2005). "MSAP enhances migration of C6 glioma cells through phosphorylation of the myosin regulatory light chain". Cellular and Molecular Life Sciences. 62 (11): 1260–6. doi:10.1007/s00018-005-5055-x. PMC 11139096. PMID 15905959. S2CID 10306386.
Bornhauser BC, Olsson PA, Lindholm D (September 2003). "MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain". The Journal of Biological Chemistry. 278 (37): 35412–20. doi:10.1074/jbc.M306271200. PMID 12826659.
Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S (March 1999). "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank". Gene. 228 (1–2): 161–7. doi:10.1016/S0378-1119(99)00004-9. PMID 10072769.
Do HT, Tselykh TV, Mäkelä J, Ho TH, Olkkonen VM, Bornhauser BC, Korhonen L, Zelcer N, Lindholm D (April 2012). "Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap)". The Journal of Biological Chemistry. 287 (16): 12602–11. doi:10.1074/jbc.M112.341248. PMC 3339997. PMID 22378787.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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